Buffalo (+6) at Baltimore, 1 (WJZ-13)
The Bills' Willis McGahee was impressive in his first career start, rushing for 111 yards last week against Miami. He'll have another tough challenge today against the Ravens, who allow 103.4 yards per game on the ground.
St. Louis (-6) at Miami, 1
Miami's third-ranked defense has not allowed a 100-yard receiver in 16 straight games, the longest current streak in the league. But the Rams have 13 100-yard receiving games in their last 16 games, the most in the league.
Detroit (+6) at New York Giants, 1
The Giants haven't started 5-1 since 1993. They lead the league with a plus-11 turnover margin; Detroit is fourth at plus-eight. Lions Coach Steve Mariucci never has lost to teams from New York that play in New Jersey (he's 3-0 vs. the Giants, 2-0 vs. the Jets).
Atlanta (+4) at Kansas City, 1
Has a 5-1 team ever been a four-point underdog to a 1-4 team? Is that possible? Perhaps it's because the Falcons are a banged-up bunch, with wide receivers Brian Finneran and Peerless Price and defensive tackle Chad Lavalais questionable and defensive tackle Rod Coleman out after an auto accident.
Jacksonville (+91/2) at Indianapolis, 1
The Jaguars have won three times this season in the last 45 seconds of the game, but the Colts have outscored opponents 59-25 in the fourth quarter. Indianapolis quarterback Peyton Manning has more touchdown passes (14) than 22 teams have touchdowns total.
Chicago (+7) at Tampa Bay, 1
The Bears have kept it close, losing by an average of just 5.5 points per game, but they're going to need a better performance from quarterback Jonathan Quinn, who's in danger of losing his job to rookie Craig Krenzel should he not improve upon his 65-yard performance from last week.
San Diego (+3) at Carolina, 1
Keenan McCardell, whom the Chargers acquired in a trade with the Bucs this week, should step right in and replace Reche Caldwell, lost for the year to a knee injury. But Coach Marty Schottenheimer hasn't said whether McCardell and free agent signee Bobby Shaw, who joined the team this week, will play today.
Philadelphia (-7) at Cleveland, 1 (WTTG-5)
The Eagles have yielded fewer points than the week before (17, 16, 13, 9, 8) in each of their first five games this season. They lead the league in scoring defense at 12.6 points per game. The Browns haven't started 4-0 at home since 1963.
Tennessee (+7) at Minnesota, 1
Getting 100 rushing yards in a game is one thing, but getting 100 before halftime is another. Tennessee's Chris Brown has done it three times this year. Vikings running back Michael Bennett should make his season debut today.
New York Jets (+61/2) at New England, 4:05 (WUSA-9)
The Patriots remained undefeated last week, but Coach Bill Belichick still wasn't happy. "I did a poor job, and a lot of the yards and points they got were just -- I should take responsibility and will take the responsibility," he said. "It was bad, bad coaching, period." To repeat, the Patriots won that game.
Dallas (+31/2) at Green Bay, 4:15 (WTTG-5, WBFF-45)
The Cowboys have been ugly in the fourth quarter, getting outscored 45-9 in all their games and 34-0 in their three losses.
Seattle (-7) at Arizona, 4:15
Jerry Rice will see plenty of action in his first game with the Seahawks, but a bad omen occurred in his first practice with the team: He dropped a pass, something Seattle's wide receivers have been doing a lot lately. "My first practice, and I had a drop, and I don't like that," Rice told the Seattle Times.
New Orleans (+3) at Oakland, 4:15
The Saints' offense is bad: They have 18 false-start penalties this year. The Saints' defense is bad: Last week against the Vikings, they gave up career-high performances to three players -- Daunte Culpepper (425 passing yards), Mewelde Moore (109 rushing yards) and Nate Burleson (134 receiving yards).
Denver (-6) at Cincinnati, Monday, 9 (WJLA-7, WMAR-2)
Denver has been on "Monday Night Football" at least once for 13 straight years. The Bengals, meanwhile, will host their first "MNF" game in 15 years and will make their first appearance in 12 years.