Chiefs 45, Colts 35

-- On a day dominated by offense, it took a defensive back to settle things.

Indianapolis star Peyton Manning had already thrown five touchdown passes when he lofted the ball into Kansas City's end zone with just less than two minutes left Sunday. This time, the catch was made by Chiefs safety Greg Wesley, who returned the ball 65 yards to seal Kansas City's 45-35 victory.

"We didn't want it to have to happen that way," Wesley said. "But they've got a powerful offense. We knew that coming in. We knew it wasn't going to be easy -- but the only thing that matters is that 'W.' "

Kansas City's win broke a seven-game losing streak against the Colts (4-3), who didn't punt in their 38-31 AFC divisional playoff victory over the Chiefs last season. Before Sunday, Kansas City (3-4) had not defeated Indianapolis since 1985 and had lost five straight to the Colts at Arrowhead Stadium.

Kansas City won back-to-back games for the first time this year, while Indianapolis lost its second straight.

"It's disappointing, because I know we can play a lot better and we're not doing it," Colts Coach Tony Dungy said.

The interception negated a huge day by Manning, who passed for 472 yards -- and kept the Chiefs from wasting spectacular performances by Trent Green and Priest Holmes.

Green threw for 389 yards and three scores, two to tight end Tony Gonzalez, and Holmes overcame an early fumble to finish with 143 yards rushing and three touchdowns.

"It was just demoralizing, having them score all the time," Colts cornerback Nick Harper said.

The Chiefs finished with 590 yards, the Colts with 505 -- the third-highest single-game combined total in NFL history.

"When you get 590 yards of offense I don't know what you left out," Chiefs Coach Dick Vermeil said. "I've never been involved in 590 yards of offense. I don't add that high.

Manning's six-yard touchdown pass to Reggie Wayne pulled Indianapolis within 38-35 with just less than 51/2 minutes left. But Green's 25-yard throw to Eddie Kennison got Kansas City to the Colts 19. Green hit Gonzalez for a 14-yard score and a 45-35 lead.

Manning, starting the ensuing drive at his 44, hit Brandon Stokley for 21 yards and Marcus Pollard for 10. On the next play, he threw into a sea of red jerseys.

"It was a bad decision on my part," Manning said. "It was just a bad throw."

Before then, Manning picked the Chiefs' defense apart seemingly at will. Only overthrows of several open receivers kept him from ringing up more yardage and at least two more touchdowns.

The Colts trailed 31-14 at the half, but Manning was 6 for 6 for 162 yards in the third quarter and pulled them to 31-28 by the end of the period on touchdown passes of 22 yards to Marvin Harrison and 41 yards to Wayne.

Holmes scored from inches out with just less than 13 minutes left in the game for a 38-31 lead.

The Chiefs stuffed a fake punt on Indianapolis's opening possession of the game, then Holmes fumbled at the Colts 5 and Idrees Bashir recovered. Two pass interference penalties helped the Colts move to their 48, and Manning hit Harrison for a 52-yard score and a 7-0 lead.

Before he can cross the goal line, Kansas City running back Priest Holmes is upended by Colts cornerback Jason David. Holmes rushed for 143 yards and three touchdowns.