Arizona (+3) at Miami, 1
The Dolphins' defense, which was the team's lone bright spot, gave up two 100-yard rushers on Monday night against the Jets. Now they'll have to play the rest of the season without inspirational leader Junior Seau, out for the season with a chest injury.
New York Jets (-3) at Buffalo, 1 (WUSA-9, WJZ-13)
The Bills have only two wins, but both came with running back Willis McGahee in the starting lineup. He scored Buffalo's only two rushing touchdowns of the season last week against Arizona.
Dallas (-1) at Cincinnati, 1
The Cowboys returned to a more Parcells-like running game last week, rushing a season-high 41 times against the Lions. It'll probably be more of the same against a Bengals rushing defense that ranks last in the league (155.4 yards per game).
Oakland (+7) at Carolina, 1
The Panthers allowed 1,772 rushing yards last season; in just seven games this season, they've already given up 1,068. But the Raiders haven't exactly been good on the ground: Their 80.8 yards per game rank 30th in the league.
Philadelphia (even) at Pittsburgh, 1
Quarterback Ben Roethlisberger has won over Steelers fans so much, he received a few write-in votes on Election Day in various races in the Pittsburgh area.
Kansas City (-3) at Tampa Bay, 1
What has happened to Dante Hall? The Chiefs' kick returner brought back four punts and three kickoffs for touchdowns last season. This season, he has yet to find the end zone and ranks 29th in the league in kickoff return average.
Chicago (+9) at N.Y. Giants, 4:05
Giants quarterback Kurt Warner has thrown just two interceptions in 202 attempts, the best attempt-to-interception ratio in the league.
Seattle (-7) at San Francisco, 4:05
Seahawks wide receiver Jerry Rice faces his former team for just the second time. He had six catches for 74 yards with the Raiders against San Francisco in 2002, but he's questionable today along with fellow wide receivers Darrell Jackson and Bobby Engram.
New Orleans (+61/2) at San Diego, 4:05
Since the Chargers' fourth game, quarterback Drew Brees has 11 touchdowns and just one interception. On defense, the Chargers lead the league against the run, allowing just 81.5 yards per game. However, they have allowed eight rushing touchdowns, ranking them near the bottom of the league.
Houston (+61/2) at Denver, 4:15
The Broncos have recorded just two sacks in their past two games, both losses and both against quarterbacks (Carson Palmer and Michael Vick) who are prone to getting sacked. The Texans have given up 16 sacks this season.
New England (-1) at St. Louis, 4:15 (WUSA-9, WJZ-13)
St. Louis is an underdog at home for just the second time since early in the 1999 season. The Rams didn't practice once over their bye week, which is the usual way things are done under Coach Mike Martz. It has paid off: St. Louis is 4-0 following bye weeks under Martz.
Cleveland (+6) at Baltimore,
After a shaky start, Cleveland quarterback Jeff Garcia has been on fire of late. He has completed 65 percent of his passes in four of his last five games and has six touchdown passes in his past three games.
Minnesota (+7) at Indianapolis, 9 tomorrow (WJLA-7, WMAR-2)
Send the Vikings on the road for a night game and they've been toast recently. In the past six seasons, Minnesota is 2-6 in road night games. The Colts' Peyton Manning and Marvin Harrison need just four completions to pass Jim Kelly and Andre Reed and become the most prolific quarterback-wide receiver tandem in NFL history.