New York Yankees third baseman Alex Rodriguez became the youngest player in major league history to hit 400 career home runs during Wednesday night's 12-3 win over the host Milwaukee Brewers.

Rodriguez, 29, hit a two-run homer to left-center field in the first inning off Brewers starter Chris Capuano and became the 40th major league player with 400 homers with a solo shot to right field in the eighth inning off Jorge de la Rosa.

Ken Griffey Jr., Jimmie Foxx and Mickey Mantle all reached the 400-homer mark at age 30. Last month, Boston Red Sox outfielder Manny Ramirez, 33, became the 39th player in major league history with 400 homers.

Rodriguez, an eight-time all-star, was 4 for 4 with four RBI, three runs scored and a walk on Wednesday. He's hitting .324 for the season, leading the majors with 19 homers and ranks second to the Brewers' Carlos Lee with 53 RBI.

"Alex had a super night and capped it off with the 400th home run," Yankees Manager Joe Torre said. "He's 29 years old and has 400 homers. That's pretty incredible. With the shape he's in and the way he works, who knows where he's going?"

Rodriguez, the 2003 American League most valuable player with the Texas Rangers and a two-time Gold Glove award winner, has a .306 average with 1,149 RBI during 12 major league seasons with Seattle, Texas and the Yankees.

The Yankees (29-30), who snapped their three-game losing streak on Wednesday, are in fourth place in the AL East, six games behind the first-place Baltimore Orioles.

They open a three-game series Friday night against the St. Louis Cardinals.