Rams36313 -- 2549ers02170 -- 28
Brandon Lloyd and Arnaz Battle caught second-quarter touchdown passes from Tim Rattay, and Mike Adams intercepted Marc Bulger's pass in San Francisco territory with 52 seconds left as the 49ers, who had the NFL's worst record last year, hung on to beat visiting St. Louis.
"Just getting rid of that stench from last year, taking advantage of this fresh start, that's what this game is," San Francisco LB Jeff Ulbrich said. "To win in a game that's truly meaningful, that's great."
Rookie Otis Amey returned a punt 75 yards for a touchdown the first time he touched the ball for the 49ers, who erupted for 21 points in the second quarter -- more than last season's 2-14 team scored in any quarter of its wretched season.
The 49ers' defense was on the field for nearly 40 minutes, but San Francisco held on for its first regular season victory in regulation since Dec. 7, 2003. Both of the Niners' wins last season came in overtime against Arizona.
The Rams' Torry Holt caught 10 passes for 125 yards, but San Francisco's defense sacked Bulger seven times.
"I don't know what word describes it, but it's certainly a big win for our team," 49ers Coach Mike Nolan said.
St. Louis: FG Wilkins 30, 4:28.
St. Louis: FG Wilkins 41, 13:07.
San Francisco: Lloyd 35 pass from Rattay (Nedney kick), 9:45.
San Francisco: Amey 75 punt return (Nedney kick), 6:48.
San Francisco: Battle 6 pass from Rattay (Nedney kick), 1:16.
St. Louis: FG Wilkins 33, :00.
San Francisco: Barlow 9 run (Nedney kick), 11:32.
St. Louis: FG Wilkins 41, 1:52.
St. Louis: Bruce 29 pass from Bulger (run failed), 13:22.
St. Louis: Manumaleuna 6 pass from Bulger (Wilkins kick), 2:13.
Rams49ersFirst Downs 2612Total Net Yards 405217Rushes-Yards 26-8921-34Passing 316183Punt Returns 2-141-75Kickoff Returns 4-555-123Interceptions Ret. 0-01-0Comp-Att-Int 34-56-113-18-0Sacked-Yards Lost 7-462-9Punts 4-33.05-41.4Fumbles-Lost 0-02-2Penalties-Yards 7-485-30Time Of Possession 39:2320:37 RUSHING
St. Louis: Jackson 19-60, Faulk 3-12, Bulger 2-8, McDonald 1-7, Manumaleuna 1-2.
San Francisco: Barlow 14-22, Gore 4-17, Rattay 2-(minus 2), Battle 1-(minus 3).
St. Louis: Bulger 34-56-1-362.
San Francisco: Rattay, 11-16-0-165, Battle 2-2-0-27.
St. Louis: Holt 10-125, McDonald 7-73, Curtis 7-63, Bruce 3-61, Jackson 3-13, Williams 1-12, Manumaleuna 1-6, Looker 1-5, Faulk 1-4.
San Francisco: Battle 5-59, Floyd 3-65, Gore 2-21, Barlow 2-17, Morton 1-30.
MISSED FIELD GOALS