Baltimore (-4) at Tennessee,
1 p.m. (WUSA-9, WJZ-13)
Ravens RB Jamal Lewis has never rushed for 100 yards against the Titans, but he's never faced a Titans defense so squeezably soft before.
Buffalo (+21/2) at Tampa Bay, 1 p.m.
Bills QB J.P. Losman looked pretty good last week in his first NFL start, but his job will be tougher today, on the road for the first time, against a defense that held Daunte Culpepper to no touchdowns, five turnovers and a career-low passer rating of 49.2 last week.
Detroit (-11/2) at Chicago, 1 p.m.
The Lions are going for their fourth straight win against the Bears, something they haven't done since winning five straight from 1971 to '73.
Jacksonville (+9) at Indianapolis,
Last season, Jaguars QB Byron Leftwich completed 52 of 71 passes for 618 yards in two games against the Colts, who welcome back S Mike Doss from a one-game suspension. Three other members of the team's secondary are either out or questionable to play.
Minnesota (+3) at Cincinnati, 1 p.m.
Two of the league's most entertaining motor mouths -- not to mention two of the league's better players at their positions -- are Bengals WR Chad Johnson and Vikings CB Fred Smoot, and they'll be chatting each other up head-to-head. Somebody, please, put a mic on these two.
New England (-3) at Carolina, 1 p.m.
Patriots QB Tom Brady and Coach Bill Belichick aim for their 50th win as a duo in just their 64th game together.
Pittsburgh (-6) at Houston, 1 p.m.
In Week 1, Ben Roethlisberger completed 9 of 10 passes for 218 yards, two touchdowns and the first perfect single-game passer rating in the NFL since 2003. Of course, RB Willie Parker carried so much of the load that Roethlisberger didn't pass enough to even qualify among the league's statistical leaders.
San Francisco (+13) at Philadelphia,
1 p.m. (WTTG-5)
Just as the Donovan McNabb-Terrell Owens-Andy Reid furor was dying down, along comes an emotionally charged matchup between Owens and his old team. And none too soon -- we're required by league rules to yak about Owens feuding with somebody.
Atlanta (+1) at Seattle, 4:05 p.m. (WBFF-45)
Which interior lineman leads the NFL in sacks from his position over the past four seasons? That would be Falcons DT Rod Coleman (with 34), who still hasn't been to a Pro Bowl.
St. Louis (+1) at Arizona, 4:05 p.m.
Cardinals QB Kurt Warner on his first game against the Rams, the team he left on less-than-good terms two years ago: "How do you have any animosity for an organization that gave the opportunities that they gave me, that allowed me to fulfill a dream when nobody else would?"
Cleveland (+61/2) at Green Bay,
4:15 p.m. (WUSA-9, WJZ-13)
Brett Favre needs only 65 passing yards to join Dan Marino and John Elway as the only players in NFL history with 50,000. But how much beyond that will he accumulate if his retooled offensive line continues to look as bad as it did last week?
Miami (+6) at N.Y. Jets, 4:15 p.m.
Jets P Ben Graham, a 31-year-old native of Australia, is the oldest rookie to start an NFL season.
San Diego (+3) at Denver, 4:15 p.m.
The Chargers welcome back TE Antonio Gates from his suspension, and perhaps also LB Shawne Merriman (Maryland), who missed Week 1 with a sprained knee.
Kansas City (-1) at Oakland,
8:30 p.m. (ESPN)
Chiefs LB Derrick Johnson had one of the league's better rookie debuts last week: nine tackles, a sack and a forced fumble.
N.Y. Giants (-31/2) "at" New Orleans, tomorrow, 7:30 p.m.
(WJLA-7, WMAR-2; continuing at
9 p.m. on ESPN)
In their long history, the Giants have had no team member rush for 7,000 career yards. That is, unless RB Tiki Barber gets 11 of them tomorrow.