Carolina (-3) at Miami, 1 p.m.
The Panthers are the only NFL team that has never beaten the Dolphins, and now that assignment appears more difficult than it did before the season, with Miami playing tough under first-year coach Nick Saban.
Atlanta (+21/2) at Buffalo, 1 p.m.
Falcons quarterback Michael Vick has a sore hamstring but is expected to play, which is good news for Atlanta. During Vick's career, the Falcons are 24-13-1 when he starts and 9-19 when he doesn't.
Cincinnati (-3) at Chicago, 1 p.m.
The difference in this contest could come down to protecting the football. The teams are 1-2 in turnover margin (Cincinnati, plus-7, Chicago, plus-6).
Cleveland (+131/2) at Indianapolis,
This game features a quarterback who's only three passing yards from the NFL lead and has a nifty 95.1 rating -- and it's the Browns' Trent Dilfer. Two-time MVP Peyton Manning, meanwhile, is 22nd in passing yardage with two touchdowns.
Tennessee (+61/2) at St. Louis,
Titans Coach Jeff Fisher goes for his 100th victory, but that will be hard to come by at the Edward Jones Dome. Since 1999, the Rams have the best home record in the NFL at 39-9.
Jacksonville (+21/2 ) at New York Jets,
It's the battle of the Marshall quarterbacks, and both have issues: The Jets' Chad Pennington appears still to be feeling the effects of offseason shoulder surgery, while the Jaguars' Byron Leftwich is still recovering from the beating he took last week by the Colts.
Tampa Bay (-31/2) at Green Bay,
1 p.m. (WTTG-5)
The Packers attempt to avoid their first 0-3 start since 1988, and Coach Mike Sherman isn't trying to sugarcoat the situation with his players, saying, "I don't think you can tell them the glass is half-full when it's not."
Oakland (+81/2) at Philadelphia,
1 p.m. (WUSA-9, WJZ-13)
Eagles tight end L.J. Smith's initials stand for "Little John," but he's put up some big numbers for a team lacking a clear wide receiving complement to Terrell Owens. Smith ranks first in the NFL at his position in yards (148) and second in receptions (12).
New Orleans (+4) at Minnesota,
If facing the Saints can't fix whatever ails Daunte Culpepper, perhaps nothing will. The past two meetings between these teams have resulted in Culpepper earning NFC offensive player of the week honors.
Arizona (+6) at Seattle, 4:05 p.m.
The Cardinals were a trendy preseason pick to make the playoffs but now desperately need a victory against a team that's won four of their past five matchups.
Dallas (-61/2) at San Francisco,
Not that the Cowboys needed any extra motivation to win after blowing their Monday night game against the Redskins, but 49ers linebacker Julian Peterson provided it anyway by publicly guaranteeing a San Francisco victory.
New England (+3) at Pittsburgh,
4:15 p.m. (WUSA-9, WJZ-13)
The Steelers could use a good test after rolling over a pair of weak teams (the Titans and Texans). Interestingly, the 14 total points Pittsburgh gave up to those squads were its fewest allowed over the first two games of the season since 1943, when war caused the franchise to merge with Philadelphia as the Steagles.
New York Giants (+6) at San Diego, 8:30 p.m. (ESPN)
Chargers fans will have something to boo about when Eli Manning, who forced the team to trade him after it selected him No. 1 overall in the 2004 draft, comes to town. "I've played in loud stadiums before, but I don't know if I've played in a place where the team had a reason to dislike me," Manning said. By around 8:15 or so, Manning will know that he has.
Kansas City (+3) at Denver, tomorrow, 9 p.m. (WJLA-7, WMAR-2)
With 55 receiving yards, Broncos wideout Rod Smith would become only the second undrafted player to reach 10,000 for his career; the first was Redskins star Gary Clark.