South Florida 45,

Louisville 14

Wide receiver Amarri Jackson ran for two touchdowns and threw for a third Saturday night to lead South Florida to the biggest victory in the school's brief football history, a 45-14 rout of No. 9 Louisville in the Bulls' Big East debut.

After barely playing a role in the offense in his team's first three games, Jackson was Mr. Versatile in helping South Florida (3-1) beat a ranked opponent for the first time in six tries and stop the nation's third-longest Division I-A winning streak at nine games.

Louisville (2-1) had not lost since a 41-38 setback at Miami last Oct. 14. The Cardinals entered the conference opener with one of the country's most prolific offenses, but never fully got on track in losing to South Florida on the road for the second time in three years.

Jackson, who had two receptions for 15 yards in South Florida's first three games, set up Andre Hall's one-yard, first-quarter touchdown run with a 57-yard catch-and-run on the Bulls' second offensive play.

The 6-foot-5 wide receiver scored on a 51-yard reverse up the right side of the field to make it 14-0, then circled left end on a 12-yard reverse for a 21-0 lead midway through the second quarter.

Despite the loss, Louisville compiled some gaudy offensive statistics. Brian Brohm completed 29 of 47 passes for 389 yards.

Louisville's Chad Rimpsey, left, and Montavious Stanley sit on the bench late in the fourth quarter of a 45-14 loss to South Florida, which snapped the Cardinals' nine-game winning streak. Louisville suffered its first defeat since a 41-38 loss to Miami last October.