Philadelphia at Kansas City: The Eagles, with one of the league's best defenses, will need to be stout in order to stop the Chiefs' many offensive weapons. Kansas City running back Priest Holmes has been a scoring machine over the past three seasons, including setting an NFL record with 27 touchdowns in 2003.

Buffalo at New Orleans: The Saints will be playing their first game at the Alamodome, one of their two temporary homes after Hurricane Katrina ravaged New Orleans and rendered the Superdome unplayable. Both teams are coming off losses. The Bills fell to the Falcons, 24-16, and the Saints lost to the Vikings, 33-16.

San Francisco at Arizona: The NFL makes its regular season debut outside the United States when the 49ers and Cardinals play in Mexico. The game figures to lack many highlights, as the teams have combined for one win this season, but it's a historic game nonetheless.

Minnesota at Atlanta: With quarterback Daunte Culpepper and the Vikings offense apparently out of their two-game funk to start the season, this game could be a high-scoring affair. The Falcons have one of the most potent rushing attacks with running backs Warrick Dunn and T.J. Duckett and quarterback Michael Vick. The Vikings' ground game finally got going yesterday behind Mewelde Moore's 104 yards rushing.

Mewelde Moore got the Vikings going with 104 yards rushing in a win over New Orleans.