Indianapolis at Cincinnati: The Colts (9-0) remain the league's only undefeated team thanks largely to quarterback Peyton Manning, running back Edgerrin James and a vastly improved defense. The Bengals (7-2) should provide a good test to see just how good the Colts are. Cincinnati's offense is formidable with quarterback Carson Palmer and wide receiver Chad Johnson, and the defense has intercepted five passes in three different games.

Carolina at Chicago: The Panthers may be the best team in the NFC after improving to 7-2 with a 30-3 victory over the New York Jets. Their offense is balanced with quarterback Jake Delhomme, wide receiver Steve Smith and a running game that includes Stephen Davis and DeShaun Foster. The Bears continue to be among the surprises in the league after improving to 6-3 with a 17-9 win against the 49ers.

Philadelphia at New York Giants: Even without Terrell Owens, the Eagles (4-4) have some of the most talented players in the league, with Donovan McNabb at the head of that list. Brian Westbrook is more of a threat out of the backfield than as a straight-ahead runner, and he is capable of turning short passes into long gainers. The Giants (6-3) will be coming off a disappointing 24-21 home loss to the Minnesota Vikings.

Edgerrin James keeps the offense grounded, but defense may be the Colts' biggest asset.