Hawaii made a short side trip a long day for No. 4 Michigan State.
Matt Lojeski and Julian Sensley each scored 20 points for the Rainbow Warriors in an 84-62 victory in Honolulu that ended the Spartans' streak of season-opening wins at 28.
"I'm at a loss for words," Sensley said. "In the world of basketball anybody can be beaten on any night."
Michigan State, the first member of the preseason top 10 to lose this season, was hampered by poor shooting and leg cramps. The Spartans stopped off on Oahu on the way to Maui Invitational that starts tomorrow and will see them play three games in as many days.
It was the biggest home win for the Rainbow Warriors (1-0) since they beat No. 2 Kansas in the finals of the 1997 Rainbow Classic. And the crowd of 8,802 got louder as the lead got larger.
Lojeski, a junior college transfer playing in his first Division I game, was 6 for 8 from three-point range and his last one capped a 14-2 run that gave Hawaii a 70-52 lead with 6 minutes 3 seconds left.
Maurice Ager had 16 points for the Spartans, coming off their fourth Final Four appearance in seven years. But he was one of four Michigan State players affected by leg cramps. Paul Davis, who had 12 points and 11 rebounds, left the game for a second and final time with cramps with 13:27 to play. Ager, Shannon Brown and Drew Neitzel all had to leave at some point because of cramps. Brown had to be removed on a stretcher with 6:36 left because of the intense pain.
"He was cramping from his neck to his feet," Izzo said. He was upset with fans behind the Michigan State bench who were booing and yelling for Brown to be dragged off the court so the game could continue.
"That's the maddest I've ever been as a coach in college," Izzo said.
* UC IRVINE 79, STANFORD 63: Ross Schraeder scored 19 points and the visiting Anteaters used an impressive shooting performance and hustle to shock No. 13 Stanford in the Cardinal's season opener.
"Ugly, ugly, ugly, ugly," second-year Cardinal coach Trent Johnson said.
Shamar Armstrong scored six straight points in the final 3 minutes 19 seconds, and the Anteaters took advantage of a significant height advantage to pound the ball inside at every opportunity against a Stanford squad missing starting forward Matt Haryasz after he sprained his ankle in practice Friday.
Darren Fells added 18 points, 9 rebounds, 5 assists and 2 blocks for UC Irvine (2-1).
* OKLAHOMA 68, SAMFORD 41: Kevin Bookout scored 13 points and grabbed 10 rebounds, and Michael Neal added 15 points on five three-pointers to help the No. 6 Sooners win at home.
Oklahoma opened the second half with a 22-5 run and led 49-22 after Nate Carter's reverse layup with 9:59 to play.
* LOUISVILLE 78, TENNESSEE-MARTIN 61: Juan Palacios had 16 points and 11 rebounds to lead the No. 7 Cardinals to the home victory in the season opener for both teams.
Taquan Dean had a poor shooting day but still finished with 18 points, 9 rebounds and 5 assists for Louisville.
The win was the 450th at the college level for Louisville Coach Rick Pitino.
* DUKE 84, DAVIDSON 55: J.J. Redick started a rally late in the first half and finished with 29 points, leading the top-ranked Blue Devils at home. Redick shot 10 for 18, including 4 for 6 from three-point range as the Blue Devils (3-0) took a break from the NIT Season Tip-Off and beat Davidson in its season opener.
* NEVADA 82, SACRAMENTO STATE 74: Nick Fazekas scored 28 points and grabbed 14 rebounds to help the No. 22 Wolf Pack (1-0) at home.
Alex Bausley scored 28 points for the Hornets (1-2).
* WASHINGTON 99, AMERICAN 82: The Huskies pulled ahead in the second half after being tied at halftime for their school-record 26th consecutive home victory.
Washington (4-0) was led by senior swingman Brandon Roy's 17 points. Andre Ingram scored 24 for American (0-1).