Bills3700 -- 10Chargers1421310 -- 48
Drew Brees threw for 339 yards and a season-high four touchdowns, including one to Antonio Gates, as San Diego rolled to its third straight win.
Gates, a star tight end who causes headaches for defensive coordinators, hurt his right foot at the end of a 21-yard reception midway through the third quarter when he was tripped up by Angelo Crowell.
Brees completed his first nine passes and threw for 265 yards to help the Chargers take a 35-10 halftime lead. Overall he completed 28 of 33 passes as the Chargers improved to 6-4. Buffalo is winless in five road games.
The Chargers had touchdowns on five of their seven first-half possessions.
LaDainian Tomlinson scored on a one-yard dive over the pile on fourth down on the game's opening drive, and it was all Brees after that.
San Diego: Tomlinson 1 run (Kaeding kick), 9:31.
Buffalo: FG Lindell 53, 6:40.
San Diego: Gates 27 pass from Brees (Kaeding kick), :32.
San Diego: Parker 23 pass from Brees (Kaeding kick), 7:22.
San Diego: Neal 2 pass from Brees (Kaeding kick), 3:12.
Buffalo: Shelton 3 pass from Losman (Lindell kick), 1:23.
San Diego: McCardell 29 pass from Brees (Kaeding kick), :37.
San Diego: FG Kaeding 28, 4:01.
San Diego: FG Kaeding 38, 14:14.
San Diego: Turner 8 run (Kaeding kick), 4:06.
BillsChargersFirst Downs 1228Total Net Yards 202478Rushes-Yards 13-6534-141Passing 137337Punt Returns 0-02-0Kickoff Returns 9-2393-51Interceptions Ret. 0-01-10Comp-Att-Int 20-36-128-33-0Sacked-Yards Lost 6-311-2Punts 4-48.51-53.0Fumbles-Lost 3-12-0Penalties-Yards 9-652-10Time Of Possession 22:3037:30RUSHING
Buffalo: McGahee 10-39, Losman 2-30, S.Williams 1-(minus 4).
San Diego: Tomlinson 19-67, Turner 8-48, Parker 1-14, McCardell 2-6, Osgood 1-4, Pinnock 1-4, Brees 1-(minus 1), Rivers 1-(minus 1).
Buffalo: Losman 20-36-1-168.
San Diego: Brees 28-33-0-339.
Buffalo: Moulds 5-38, Evans 4-69, Parrish 2-14, Euhus 2-12, Shelton 2-7, S.Williams 2-2, Aiken 1-15, Reed 1-9, McGahee 1-2.
San Diego: McCardell 6-88, Gates 5-77, Neal 5-22, Parker 4-69, Caldwell 3-40, Tomlinson 3-22, Osgood 1-15, Sproles 1-6.
MISSED FIELD GOALS