Tampa Bay at Carolina: The two top teams in the NFC South meet for the division lead. A Buccaneers win would move them into a tie for first, and a Panthers win would give Carolina a two-game lead and season sweep of Tampa Bay. The Buccaneers (8-4) are coming off a 10-3 victory over the Saints. The Panthers (9-3) handled the Falcons, 24-6, to end a five-game losing streak against their division rival.

Indianapolis at Jacksonville: The Colts (12-0) continue toward a perfect season after dismantling the Titans, 35-3. Quarterback Peyton Manning threw three touchdowns, and defensive tackle Larry Tripplett scored on a 60-yard fumble return. The Jaguars (9-3), who are without quarterback Byron Leftwich, got two touchdown passes from backup David Garrard in a 20-14 win against the Cleveland Browns.

Chicago at Pittsburgh: The Bears (9-3) have won eight in a row for the first time since they won their only Super Bowl in the 1985 season. In a 19-7 victory over the Packers yesterday, the Bears held future Hall of Fame quarterback Brett Favre without a touchdown pass. The Steelers (7-5) are coming off a 38-31 loss to the Bengals and need a win to remain a viable contender in the crowded AFC playoff chase.

Jaguars QB David Garrard threw two touchdowns vs. Browns.