Another major retailer bites the dust.

Filene’s Basement will close all 46 of its stores, the chain announced Wednesday. (Tannen Maury/Bloomberg)

The chain currently has three locations in the District, at 529 14th Street (in the National Press Club building), at 1133 Connecticut Ave. and in the Mazza Gallerie at 5300 Wisconsin Avenue. It has a store in Rockville, at 11840 Rockville Pike, as well as in Baltimore’s Inner Harbor.

Syms expects the closures to be complete by January of 2012 — after the holiday shopping season — but has not announced a timeline for specific stores. Staff at the Filene’s Basement stores in Rockville, Friendship Heights and the National Press Club building declined to comment.

The local stores average about 30,000 square feet per store, meaning the closures will open up about 150,000 square feet of space in the area.

Filene’s joins a growing list of well-known retailers that have had difficulty outlasting the sluggish economy and decided to either close up altogether or pull back, creating holes in shopping centers, malls and downtown streets. All Borders book stores have liquidated and many of the vacancies have not been filled, including those downtown and in Friendship Heights. Lowe’s also announced last month that it would close 20 stores.

You can read the Syms bankruptcy filing here .

Staff reporter Danielle Douglas contributed to this report.