Seth MacFarlane returns to his roasting duties for Comedy Central. (PHIL McCARTEN/REUTERS)

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#Grinning.

Seth MacFarlane is continuing to grow his portfolio beyond dominating Fox’s Sunday-night animation block. The “Family Guy” creator will bring his toothy grin and cheeky sense of humor to Comedy Central next month — to host the network’s roast of Charlie “Winning!” Sheen.

“I’m very excited to work with Comedy Central again on the roast,” MacFarlane said in a statement Thursday, already prepping his quips. “Charlie is a true icon with a talent that is strong and pure and concentrated into small crystals which can be smoked or eaten.”

Sheen, of course, was booted from the top-rated CBS sitcom “Two and a Half Men” earlier this year, as the actor went out in a blaze of tweets and soundbites. The roast will be taped Sept. 10 in Los Angeles for a Sept. 19 airdate — the same night Ashton Kutcher debuts on “Two and a Half Men.”

MacFarlane has previously hosted roasts of Donald Trump and David Hasselhoff. The “American Dad” and “Cleveland Show” creator/producer/voice-actor — always a fan of musical spoofery — has also been plunging into a singing career, crooning American standards for recording and performance.

MacFarlane has recently announced two projects of very different tones: He said he will help bring “Cosmos” back to TV — and he will reboot “The Flintstones.”

“In addition to his sharp wit, Seth is way more suave and sophisticated than we are,” Kent Alterman, Comedy Central’s programming honcho, said in the statement. “We continue to try and soil him.”

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