Yabba-dabba do-over!

So can say Fox animation dominator Seth MacFarlane, who is getting the chance to remake one of his favorite old cartoons: “The Flintstones” — an announcement that will surely be met with both clapping hands and much hand-wringing.

“I think America is finally ready for an animated sitcom about a fat, stupid guy with a wife who’s too good for him,” said the oft off-color MacFarlane in a statement to advertisers at the TV Upfronts in Manhattan — noting that Fred Flintstone was one of the first cartoons he ever drew as a child.

MacFarlane’s version of Bedrock, however, won’t go into production till later this year — meaning it won’t air till 2013 soonest.

Fox — which airs MacFarlane’s animated shows “Family Guy,” “The Cleveland Show” and “American Dad” — said it hopes to bring “The Flintstones” to a “whole new generation.”

No word on whether Fox will let MacFarlane ratchet up the raunch among Fred, Wilma and the rest of the half-century-old cartoon characters who were inspired by “The Honeymooners.”

Bill Hanna and Joe Barbera launched “The Flintstones” 50 years ago last fall. The original series (1960-66) about the modern Stone-Age family is the godfather of “The Simpsons,” “King of the Hill,” “Family Guy” and so many other prime-time cartoons that draw legions of adult viewers.

Till 2013, let the “Flintstones”/”Family Guy” mashups spring forth.

(Note: You can follow the TV Upfronts coverage by Post TV columnist Lisa de Moraes, who is reporting from Manhattan.)

MORE: At 50, “The Flintstones” stand up as the bedrock of prime-time animated comedy

MORE: “Cleveland Show’s” Kevin Michael Richardson voices his fandom of MacFarlane.

Given MacFarlane’s track record with the Flintstones and Rubbles, we can fairly anticipate that his reboot will go in this “edgier” direction (and a reminder: We did say the “oft off-color McFarlane”):