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One man was shot fatally and three were wounded late Saturday afternoon near the campus of Howard University and the route of the Caribbean Festival parade.

The gunfire occurred a few minutes after 5 p.m. on Gresham Place NW, near Georgia Avenue NW, the thoroughfare along which thousands of people had watched or taken part in the parade.

It appeared that the parade had largely passed, but many people had remained near the route when the shooting suddenly erupted. Witnesses said the sounds sent people fleeing down Gresham Place and away from Georgia.

Assistant Police Chief Diane Groomes said the shooting had no connection to the festival or the university. Investigators believed it stemmed from a neighborhood matter, she said.

At least three of those hit were from outside the neighborhood, Groomes said. The man who was killed was in his 20s or 30s and came from Alexandria, she said. He died at a hospital.

Police said 20 or more shots were fired.

“It is unbelievable that this could happen,” said D.C. Council member Jim Graham (D-Ward 1). “There were police everywhere.” Graham said he had been in the parade.

Mayor Vincent C. Gray (D) also went to the shooting scene Saturday evening.

Of the three were wounded, two were male and one female, authorities said.

Police said a gun was found near Gresham Place, a one block street that runs between Georgia and Sherman Avenues, near the northwestern edge of the Howard Campus.

Meanwhile, in a separate, but apparently unrelated incident, a stabbing occurred several blocks to the south at Georgia Avenue and W Street, police said. Groomes said that it was not connected to the shootings, and that an arrest had been made.

Staff writer Martin Weil contributed to this report.