The Giants hope to have both Nicks (left) and Victor Cruz in the lineup Wednesday. (Bill Kostroun/AP)

Chief among them is wide receiver Hakeem Nicks who had offseason foot surgery and is one of six Giants listed as questionable on the injury report.

Nicks played just two offensive series this preseason as he worked his way back into game shape. But while he is not 100 percent, Nicks is determined to be on the field when the Giants face the Cowboys in the NFL’s opener.

“It’s not that it’s perfect,” Nicks told the New York Post when asked about the foot in which he suffered a broken toe in May. “But it’s nothing that is going to stop me from playing.”

As one half of New York’s potent wide receiver duo that includes big-play threat Victor Cruz, Nicks could give the Cowboys’ new cornerback tandem of rookie Morris Claiborne and Brandon Carr fits if Eli Manning can connect with him.

Linebackers Mathias Kiwanuka (groin) and Michael Boley (hamstring), cornerback Jayron Hosley (toe), running back Da’Rel Scott (knee) and defensive end Adrian Tracy (hamstring) are also listed as questionable for the game.

Starting running back Ahmad Bradshaw, who bruised his hand in an Aug. 18 preseason game, is listed as probable and should split carries with first-round draft pick David Wilson.

On the Dallas side, tight end Jason Witten is recovering more quickly than expected from his lacerated spleen, but is listed as doubtful for Wednesday.

Starting wide receivers Miles Austin (hamstring) and Dez Bryant (knee), who were both limited by injuries in the preseason, are listed as probable.

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