Domenik Hixon with an acrobatic TD catch Monday night. (Nick Laham / GETTY IMAGES)

Hixon had an amazing 22-yard catch for his first touchdown since 2009 in the Giants’ victory over the St. Louis Rams on Monday night, but thought he’d hurt his calf on the play. He tried to play in the second half, but Coach Tom Coughlin took him out of the game because he was favoring his leg. He caught two passes in the game for 29 yards.

The loss of Hixon is the latest in a long string of injuries for the Giants, who have placed five players on the injured-reserve list or waived them with an injury settlement since July 30. Hixon, 26, was the team’s third receiver and primary punt returner in the first two games. He missed all of last season after tearing his ACL in minicamp in June 2010.