For the first time several federal agencies are setting up drop-off points for employees to safely dispose of expired or unneeded prescription drugs.

The effort is part of the second annual National Prescription Drug “Take-Back” Day, scheduled for Saturday and organized by the Drug Enforcement Administration and the Office of National Drug Control Policy (ONDCP).

Ahead of Saturday’s events, the Office of Personnel Management, White House, and departments of Health and Human Services, Justice and Transportation will set up drop-off points on Friday for unneeded or expired medication at Washington-area offices.

Prescription drug abuse is one of the nation's fastest-growing drug programs. The National Survey on Drug Use and Health has found that nearly a third of people who used drugs for the first time in 2009 began by abusing prescription drugs. Drugs that are not disposed of properly can also cause environmental damage, according to the ONDCP.

The office said the first take-back day last September yielded more than 121 tons of unneeded or expired prescription drugs with about 3,000 state and local law enforcement agencies participating.

Here’s a list of federal “Take-Back” sites scheduled for Friday:

Office of Personnel Management:

• 1900 E Street, NW, Washington

Justice Department:

• Main Office: 9th Street, 950 Pennsylvania Ave. N.W., Washington.

• Drug Enforcement Administration: 600 Army-Navy Drive, Arlington.

Executive Office of the President:

• NEOB Health Unit

Department of Transportation:

• 1200 New Jersey Avenue S.E., Washington.

Department of Health and Human Services:

• Main Office: 200 Independence Avenue S.W., Washington.

• Food and Drug Administration: 10903 New Hampshire Avenue, Silver Spring.

• Substance Abuse and Mental Health Services Administration: One Choke Cherry Road, Rockville.

• National Institutes of Health: 9000 Rockville Pike, Bethesda.

• Parklawn Building: 5600 Fisher’s Lane, Rockville.