The Washington Redskins on Sunday will take on the hosting Seattle Seahawks for the 15th time in the history of the franchises, with the Redskins holding a 10-4 advantage.

The Redskins have lost six straight games while the Seahawks are coming off of back-to-back victories. Seattle enters the game as the four-point favorite and this season is 6-3 against the spread and 2-2 at home overall.

Washington, meanwhile, owns a 1-4 record on the road.

Here are some key matchups for Sunday’s game between the Redskins and Seahawks.

WSH RT Jammal Brown vs. SEA DE Chris Clemons
The former Redskin has settled in nicely with the Seahawks in the last two seasons, recording 11 sacks last season and eight sacks this season. Brown will spend the majority of the game trying to fend off Clemons, but Clemons does move around a little bit and could test Trent Williams as well. No other Seahawks player has more than two sacks, so the Redskins will be zeroed in on Clemons in their pass protection schemes. Rex Grossman aims to build on last week’s effort, but he won’t have a chance if he’s under pressure all game long.

WSH ILB London Fletcher vs. SEA RB Marshawn Lynch
Fletcher leads the Redskins with 96 tackles and will lead the charge in stopping Lynch, who leads Seattle with 593 yards and six touchdowns on 156 carries. Fletcher has been hobbled by a sprained ankle but has remained effective. Lynch also can pose a threat as a receiver out of the backfield. The Redskins did a better job against the run last week as they took on the Cowboys’ DeMarco Murray and limited him to 73 yards on 25 carries – well below his average. Second-year pro and fellow inside linebacker Perry Riley has helped shore up the run defense since taking over as starter.

WSH WRs Jabar Gaffney and Santana Moss vs. SEA CBs Richard Sherman and Brandon Browner
Gaffney is coming off of his best outing as a Redskins receiver, posting seven catches for 115 yards and a touchdown. Moss, meanwhile, is expected to return to the lineup after four weeks on the sideline with a broken left hand. They will face the biggest cornerback tandem in the league in Seattle’s Sherman and Browner, who stand 6-foot-3 and 6-foot-4, respectively, and they could pose some problems with that size. Seattle ranks 15th in the league with 233 yards a game, while Washington ranks 16th in the league in passing offense (229 yards per game).

WSH RB Roy Helu vs. SEA LB David Hawthorne
The Redskins still are trying to find a way to get their rushing attack going, and Helu has been the only productive back since Tim Hightower went down against Carolina, this season averaging 4.9 yards a carry. Hawthorne ranks second on Seattle’s defense with 65 tackles. The Seahawks rank eighth in the league against the run (100 yards per game), and Washington has mustered only 84 rushing yards per game (30th in the league), so Helu & Co. will face a tough task.

WSH CBs DeAngelo Hall and Josh Wilson vs. SEA WRs Doug Baldwin and Sidney Rice
Hall seeks redemption from last week’s coverage breakdowns against Dez Bryant, and Wilson hopes to be healthy enough (hamstring) to face his former team. Baldwin leads Seattle with 32 catches for 544 yards and two touchdowns. Meanwhile, Rice — who missed the first two games of the season — boasts a huge size advantage over both Washington corners, standing 6-foot-4. Rice this season has 32 receptions for 484 yards and two touchdowns. Look for tje Seahawks to try to take advantage of Washington’s diminutive cornerbacks as they aim to pick up their third straight victory.