D.C. United star Dwayne De Rosario suffered a knee injury during Canada’s World Cup qualifier against Panama on Tuesday and will undergo an MRI exam upon his return to Washington.

The Canadian medical trainer told United officials he suspected De Rosario, the 2011 MLS most valuable player, hurt the medial collateral ligament, D.C. General Manager Dave Kasper told the Insider on Wednesday morning.

De Rosario left the match, a 2-0 Canada loss in Panama City, in the first half. He is scheduled to land in Washington on Wednesday and have the MRI on Thursday.

Depending on the severity, Kasper said, De Rosario would probably miss between 10 days and four to five weeks.

Even under the best-case scenario, he seems certain to miss Saturday’s match against the New England Revolution at RFK Stadium as well as next Thursday’s game at Philadelphia and a home date three days later against Chivas USA.

United (12-10-5) is one point out of an Eastern Conference playoff spot with seven matches remaining. De Rosario, one of seven players in league history to record 100 regular season goals, is tied for second in MLS with 12 assists and tied for second on the club in goals with seven. He has appeared in all but one league match and started 25 of 27.

A long-term injury would also impact Canada’s World Cup qualifying effort. The Canadians are tied for second place in CONCACAF’s Group C and have two matches remaining, Oct. 12 and 16.

The injury comes one year and one day after United’s Chris Pontius broke a leg in a game at Chivas USA — a season-ending injury that ultimately derailed D.C.’s playoff push.