David Caruso on “CSI: Miami.” (MONTY BRINTON/CBS)

Act like Horatio Caine Day is destined never to become a national holiday as we had hoped: CBS has canceled “CSI: Miami.”

“CSI: Miami” leaves an amazing television legacy – a signature look and style, global popularity and as a key player in CBS’s rise to the top over the past decade,” the network said Sunday in a statement about the camptastic David Caruso vehicle for sunglass donning.

CBS chief Leslie Moonves had hinted to investors weeks ago that one of the “CSI” spinoffs was going to get it in the neck, in order to clear way for fresher programming. But most money was on lackluster “CSI: NY,” particularly since “CSI: Miami” enjoys strong overseas sales and AMC recently closed a deal to air reruns — including an 11th season if it was ordered.

Less spectacularly, CBS also canceled freshman shows “A Gifted Man,” and ‘NYC 22” and “Unforgettable.” Raise your hand if you are surprised… Nope, no one.

However, CBS confirmed “Two and a Half Men” will be back for another season with Ashton Kutcher, Jon Cryer and Angus T. Jones.

Getting back to that fresh material for which Horatio has laid down his life: CBS has picked up a new drama starring Dennis Quaid as a rodeo star turned mayor of Las Vegas, a Sherlock Holmes update set in modern New York, a drama about street smart chick attorney in Manhattan and makes it in Manhattan, and one about a young cop’s meteoric rise to commissioner.

Comedy-wise, CBS has ordered “Partners,” about two male business partners, one’s gay, one gets married and hilarity ensues; and “Friend Me,” about two guys who to Los Angeles to work for Groupon. Quick, before the layoffs start.

More from Upfront Week:

NBC reveals schedule: ‘Community’ to Friday, ‘The Voice' to launch in fall

CW orders five new shows including ‘Carrie Diaries,’ renews ‘Gossip Girl,’ ‘Nikita,’ ‘Hart of Dixie’

ABC picks up more seasons of ‘Happy Endings,’ ‘Scandal,’ ‘Wife Swap’

NBC renews ‘Parks and Recreation,’ ‘The Office,’ ‘Up All Night,’ ’Whitney’

An early look at Upfront Week 2012

NBC renews ‘Community,’ '30 Rock,’ ‘Parenthood’

‘Cougar Town’ moves from ABC to TBS

Fox picks up mob doc, serial killer show, Mindy Kaling comedy

Fox re-ups ‘Touch,’ abandons ‘Alcatraz’

NBC renews ‘Law & Order: SVU’ for a 14th season

NBC orders comedy about dysfunctional First Family

NBC picks up shows starring Anne Heche, Matthew Perry; plus, Ryan Murphy comedy and JJ Abrams drama