1. What’s the worry?
There is always a concern when a new pathogen emerges in a population because people typically lack immunity to it, and there usually aren’t specific treatments or vaccines available. Novel coronaviruses (not seen in humans before) represent a particular concern because they have been known to spark complicated outbreaks that have sickened thousands of people, like SARS did as it swept across the globe from southern China.
2. How does this compare?
The outbreak in Wuhan, a city of 11 million, that began in mid-December appears severe. A few cases have been confirmed elsewhere in China and nearby countries involving travelers arriving from Wuhan. Initially it seemed the virus wasn’t transmitted readily between people, reducing the potential of it spawning a SARS-like outbreak. But on Jan. 20 the World Health Organization confirmed “some limited human-to-human transmission,” not just from animals to humans. Chinese state media also reported health-care workers had been infected. That put the Wuhan virus in a category similar to SARS. “The one good factor, I guess, at the moment seems to be the low mortality rate,” said Sanjaya Senanayake, associate professor of medicine at the Australian National University.
3. How serious is the virus?
At this stage, it appears to be less virulent, and less deadly, than SARS. Of the first handful of deaths linked to the virus, at least some were people who already were seriously ill. Regular pneumonia kills about 50,000 people annually in the U.S.
4. What are the symptoms?
Mainly fever, with some patients experiencing fatigue, a dry cough and difficulty breathing. Chest X-rays have shown invasive lesions of both lungs, the WHO said. However, only cases requiring hospitalization have been reported so far. It’s possible other people have been infected and experienced no, or only mild, symptoms. Many people have recovered and been discharged from the hospital.
5. What’s the cause?
Chinese authorities identified a novel coronavirus in one of the pneumonia patients in Wuhan after conducting gene sequencing. The WHO has labeled the new virus 2019-nCoV. A report done for the International Journal of Infectious Diseases found it is at least 70% similar in its genetic makeup to the SARS virus, but “appears clinically milder” in terms of severity, fatality rate and transmissibility.
6. Where did it come from?
Genomic data was made publicly available in mid-January, enabling scientists anywhere to study its genetic fingerprint for clues about where and how it might have emerged. Investigators in Wuhan have focused on the wholesale market, where most people infected early in the outbreak either worked or shopped frequently. It has been closed since Jan. 1, though cases continued to appear, including in people who hadn’t gone to the fish market. That raised the possibility that the pathogen is lurking more widely in the city.
7. How long does it take to identify?
It can vary. HIV, for example, wasn’t discovered as the cause of AIDS for years. In the case of SARS, many of China’s top doctors were initially adamant they were dealing with pneumonia caused by chlamydia, a sexually transmissible bacterium. China fired its then health minister, Zhang Wenkang, for mishandling that crisis. Wuhan houses China’s first maximum bio-containment laboratory, built in 2015 to investigate the planet’s most dangerous pathogens, so it’s well placed for the current outbreak.
8. What are authorities doing?
Chinese President Xi Jinping ordered resolute efforts to curb its spread ahead of the Lunar New Year holiday, when many people travel. Airports have begun screening some passengers for symptoms, including in the U.S. China’s health commission decided to include the coronavirus in the Class B infectious diseases category, which includes SARS, while taking preventive steps typically used for the most-serious ailments, such as cholera and plague. Patients have been isolated to prevent any spread. Health officials are also looking for, screening and monitoring people the patients had contact with, and searching for current and past cases that may have been treated in medical institutions throughout the city. Environmental samples from the closed market have been taken for analysis.
9. How else does it compare to SARS?
There are parallels. Both viruses emerged in China. SARS is thought to have spread indirectly from a “wildlife reservoir,” believed to be bats, to humans via masked palm civets and other species in live-animal markets. The SARS outbreak began in late 2002 in Guangdong province and spread across the border to Hong Kong and beyond. The WHO issued a global health alert in March and didn’t declare the outbreak contained until July 5. China’s tourism, transportation and retail sectors were heavily hit as people stayed home; domestic consumption fell sharply, as did real estate prices and financial markets. The epidemic subtracted an estimated 0.8 percentage point from gross domestic product growth in China in 2003, according to a China Daily report that cited a National Bureau of Statistics official. A 2003 academic study estimated the global economic cost at close to $40 billion or more.
10. What’s a coronavirus?
There’s a large family of them, with some causing less-severe diseases, some more. Some transmit easily from person to person, while others do not. There’s growing recognition of the role of coronaviruses in cases of severe pneumonia. The WHO says that new ones emerge periodically in different areas globally, and several known coronaviruses are circulating in animals that haven’t infected humans. They tend to morph and mutate a lot, which means the level of risk they pose can change the longer they circulate. Diseases transmissible from animals to humans, sometimes referred to as “zoonoses,” comprise a large percentage of all newly identified infectious diseases.
--With assistance from Dong Lyu, Lin Zhu and Grant Clark.
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