In this 2002 photo, Oregon Symphony music director James DePreist conducts from the podium for the first time since kidney transplant surgery in Portland, Ore. DePreist, one of the first African-American conductors and a National Medal of Arts winner, died Friday, Feb. 8, 2013. (Steven Nehl/AP)

James DePreist, one of the few black conductors to lead major orchestras in the United States and abroad, died Feb. 8 at his home in Scottsdale, Ariz. He was 76.

The cause was complications from a heart attack last spring, said his manager, Jason Bagdade.

Mr. DePreist overcame polio in his 20s to pursue a conducting career that took him to stages from Washington to New York City to Sweden to Japan over four decades. His longest and most distinguished tenure was with the Oregon Symphony, where he was music director from 1980 to 2003, a period when it gained national and international renown.

In 2010, he assumed the top musical post at the Pasadena Symphony in California.

“He had this aura about him. He didn’t have to say anything. It was the way he looked at you and held himself,” said Paul Jan Zdunek, chief executive of the Pasadena Symphony Association. “And his musicianship was beyond reproach.”

In this 2003 photo, music director James DePreist conducts the Oregon Symphony during the tribute concert at Schnitzer Hall in Portland, Ore. DePreist, one of the first African-American conductors and a National Medal of Arts winner, died Friday, Feb. 8, 2013. (Motoya Nakamura/AP)

Mr. DePreist was also permanent conductor of the Tokyo Metropolitan Symphony Orchestra and director emeritus of conducting and orchestral studies at the Juilliard School in New York.

He was a nephew of Marian Anderson, the celebrated contralto whose 1939 concert on the steps of the Lincoln Memorial was a civil rights milestone. Mr. DePreist was awarded the National Medal of Arts, the nation’s highest honor for artistic achievement, by President George W. Bush in 2005.

He had a commanding presence, even though in his last years — after a kidney transplant in 2001 — he conducted from a wheelchair.

James Anderson DePreist was born Nov. 21, 1936, in Philadelphia. His Aunt Marian Anderson was an influence early in his life. After his father died when Mr. DePreist was 6, she helped support him and his mother and encouraged his interest in music.

He entered the University of Pennsylvania’s Wharton School as a pre-law student and received a bachelor’s degree in 1958. Realizing that he did not want to be a lawyer, he switched gears, receiving a master’s degree in the arts from the University of Pennsylvania in 1961 and studying with noted composer Vincent Persichetti at the Philadelphia Conservatory of Music.

In college, he formed a jazz group called the Jimmy DePreist Quintet, which performed on “The Tonight Show” with Steve Allen in 1956.

In 1962, the State Department invited Mr. DePreist to teach and perform jazz on a cultural exchange tour of Asia. In Thailand, he was given the opportunity to conduct a Bangkok orchestra, which was “that kind of revelatory experience that we read about and hope for.” He knew he wanted to be a conductor.

But during the tour, he was stricken with polio, which left his legs paralyzed. He returned to the United States for six months of intensive therapy and regained the ability to walk with crutches. In 1964, he won first prize in the Dmitri Mitropoulos International Conducting Competition, which brought him wide notice and a season at the New York Philharmonic as an assistant to conductor Leonard Bernstein.

Finding it difficult to obtain a serious classical conducting position in the United States, he went abroad and made his European debut in 1969 leading the Rotterdam Philharmonic.

He was associate conductor under Antal Dorati of the National Symphony in Washington in 1971 when he conducted at DAR Constitution Hall, the venue that had turned away his aunt in 1939 because she was black. After one rehearsal, he called her and said, “You know, it’s incredible to me that you couldn’t do what I just did,” he told the Associated Press in 2002.

He became the first black conductor of the Houston Symphony in 1976. That year he also began a seven-year stint as music director of the Quebec Symphony.

In 1980 he was hired as music director of the Oregon Symphony, and over the next several years amplified its budget, raised players’ salaries and stretched its repertoire to include more American music. He “built it into a virtuoso band more than able to hold its own in any international company,” Gramophone magazine wrote in 2001.

Mr. DePreist made more than 50 recordings, including a critically acclaimed Shostakovich series with the Helsinki Philharmonic.

He also published two volumes of poetry, “This Precipice Garden” and “The Distant Siren.” Maya Angelou praised his work for having “the tautness of a perfectly pitched viola and much of its resonance.”

Mr. DePreist stood with leg braces to conduct until one day in Stockholm when he was conducting with violinist Itzhak Perlman, also a polio survivor.

“He asked me, ‘Why are you standing up?’ I had no good reason, and from that point on, I sat to conduct, and it was tremendously freeing.”

Survivors include his wife of 32 years, Ginette DePreist; two daughters from a previous marriage, to Betty Childress; and two grandchildren.

— Los Angeles Times and staff reports