Kathy Griffin sharpened her tongue just in time for her show at the Kennedy Center this weekend. (Tyler Shields)

With a Guinness World Record-setting 23 stand-up specials, two Emmys, a Grammy and a handful of television shows, Kathy Griffin has earned the right to tour “Like a Boss.” Griffin, 54, has never been one to shy away from controversy, making a career out of pointed pop culture observations, celebrity jokes galore and a mouth that spews whatever it wants, whenever it wants. (Remember when she dropped the F-bomb while hosting CNN’s live New Year’s Eve broadcast with Anderson Cooper?) When she headlines the Kennedy Center’s opulent Concert Hall on Saturday, fans can be sure to hear the comedian’s thoughts on Caitlyn Jenner, the GOP’s growing list of presidential hopefuls and whatever else enters her crosshairs.

Tell me a little about the “Like a Boss” tour. 

Really, what is fun about having been in the game this long, is you get to play all the venues. Let me tell you something, honey: I’ve seen the real America. When people talk about the real America, that’s where I am. I’m not just playing the blue states and the big cities. I’m going to cities that even I haven’t heard of. And that is what I love about the road. Every audience is different.

How are D.C. crowds different?

The Kennedy Center audience is like no other. It’s like the perfect combo, being super smart but not stuffy. Just be prepared — I will be making fun of people, places and things.

How does it feel to perform at such an iconic venue? 

It is iconic, and I couldn’t be there at a better time. Between Cat — as I call her, [actually, I’m] going ahead and calling Caitlyn [Jenner] Caty, because I am assuming we are destined to become besties — and also, maybe when I’m there, the decision [will be] coming down about the legalization of gay marriage.

I mean, there’s so much going on. Not to mention, could it be a better town to talk about the Republican lineup alone? Look, we can talk Hillary [Clinton], we can talk Elizabeth Warren — and you know what, I’m ready for both of them. Stop making me choose! My dream is a Hillary/Elizabeth Warren ticket, but a girl can only dream — and by the way, that could be a quote from Caitlyn Jenner.

How did you settle on the “Like A Boss” tour’s name?

I think it’s such an exciting time. I’m doing all new material. I’m doing 80 cities this year. I’ve earned “Like A Boss.”

Is there any juicy celebrity gossip you want to tell me about?

I went to a party at Chris Colfer’s house from “Glee.” I sat next to Academy Award nominee June Squibb, and on my left was Jane Lynch. And Jane Lynch and I did the color commentary.

That sounds like fun. 

And then my boyfriend and I went to see Lady Gaga and Tony Bennett at the Hollywood Bowl. And the kicker is that Lady Gaga gave me a box of eggs that her own chickens hatched.

Really?

Last night, I don’t know what you ate, but I’ll tell you right to your face, you can’t top what I had. I had a Lady Gaga omelet. You’re not going to interview anybody else, probably in your life, that’s going to say, “Oh, and last night I had a Lady Gaga omelet.”

That’s why the “Like a Boss” tour is essential. I’m going to say things at the Kennedy Center — I don’t care who they’ve honored! And damn it, they may never honor me, but I’m still going to sell out that f—ing venue, and I’m going to stand there and talk about how Lady Gaga gave me eggs and I ate a Lady Gaga omelet. And no one — not even the president — can say that!

Kennedy Center, 2700 F St. NW; Sat., 8 p.m., $49-$99.

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