“Every case of congenital syphilis that we see is an absolute, shameful failure of public health because it is completely preventable,” said Khalil Ghanem, deputy director of education at Johns Hopkins Bayview Medical Center. “We in the United States, a very wealthy country, should not have the rates of congenital syphilis that we have. It’s a scandal.”
Curable sexually transmitted diseases, in general, are on the rise around the world. The World Health Organization recently said that there are more than 1 million new sexually transmitted infections every day across the globe.
Congenital syphilis is easily preventable when pregnant women are properly screened for syphilis during their pregnancies and given antibiotics to treat it. “The trouble is, we’re just not preventing it,” said Virginia Bowen, an epidemiologist in the CDC’s Division of STD Prevention.
Bowen said an increasing number of pregnant women are either not being tested and treated early enough in their pregnancies, or they are acquiring the STD after they have already been screened for it.
And those with untreated syphilis may pass it on to their babies. According to the CDC, as many as 40 percent of babies born to mothers who have the disease may be stillborn or die soon after birth. Other babies may be born prematurely or with a low birth weight, have severe anemia, an enlarged liver and spleen, bone deformities or meningitis.
However, experts say, many babies may have no symptoms at all at birth, and the test for the disease isn’t reliable in newborns. Only a few states require testing of the mother at the time of delivery or if a woman is at high risk of infection. If the mother tests positive, both the mother and newborn are treated.
Babies who are not treated for the disease may go on to develop deafness or blindness, though experts say it is rare because physicians, particularly in high-risk communities, usually treat babies suspected to be infected.
“There’s a systems failure somewhere,” Bowen said. “It’s either at the health-care level or public health level, but somehow we are failing these women.”
Public health authorities say the rising rate of congenital syphilis reflects a rising number of cases of syphilis in adult communities. And the contributing factors that limit pregnant women’s access to proper prenatal care are complex — including mental illness, drug abuse, poverty and the stigma of STDs. “I wish I could say there’s a smoking gun. There isn’t. There are barriers in women’s lives” that keep women from getting prenatal care, increasing their risk for untreated infection, Bowen said.
The highest rate of congenital syphilis cases has been in Louisiana, where the rate is four times the national average. The state reported 59 cases in 2017, a 23 percent increase from the previous year, with the highest numbers recorded in the Lafayette, Monroe and Shreveport areas, according to data from the state’s health department.
The majority of the Louisiana mothers, 85 percent, who had babies with congenital syphilis were black, and more than half of them were younger than 25, the data shows.
Although most of the mothers received prenatal care at least two months leading up to delivery, 14 percent were not screened for syphilis in a timely manner. And of the mothers who were, 50 percent were not retested in the third trimester — a crucial time for preventing transmission — and 68 percent were not retested at all.
John Vanchiere, vice chairman for pediatric research at Louisiana State University Health Shreveport, said his team evaluates two to four babies per month for congenital syphilis. In the vast majority of cases, Vanchiere said, pregnant women are screened early in their pregnancies and either test negative or positive and are successfully treated for the infection, but then acquire syphilis later in the pregnancy.
In one recent case in Shreveport, Vanchiere said, a woman who had initially tested negative for syphilis became ill about halfway through her pregnancy after acquiring the STD. She went into labor, and her son was delivered at about 25 weeks of gestation. Within 48 hours, the baby died, Vanchiere said.
Vanchiere said that with proper medical intervention, the prognosis for babies who survive is “very good.” But it is “heartbreaking when an infant dies,” he said. “Mothers and fathers, especially when there is infectious disease transmission to the baby, often carry a lot of guilt about that because these are preventable diseases.”
Louisiana and four other states with the most cases of congenital syphilis — California, Texas, Florida and Arizona — account for 70 percent of cases in the nation; the highest per-capita rates after Louisiana are in Nevada, California, Texas and Florida.
But in Louisiana, preliminary numbers for 2018 show a 22 percent drop in the number of cases of congenital syphilis — a drop that public health authorities say comes after the implementation of policies and programs to prevent infection. For example, in 2014, state health officials worked with lawmakers to pass state legislation requiring women to be screened upon their first visit and during their third trimester, as well as at the time of delivery, to help determine whether the newborn should be treated. Most states laws require testing in the first trimester, but only a few other states call for testing at all stages.
In 2016, Louisiana assembled review boards to examine all cases of congenital syphilis across the state and determine which ones could have been prevented and how. Since then, Louisiana has reviewed 178 cases, according to the CDC, which gave the state a supplemental grant for prevention.
Louisiana has assigned case managers in two high-risk regions of the state to act as liaisons between doctors and patients, assisting women throughout their pregnancies and helping them and their partners access the proper STD care. Public health nurses in several regions make contact with pregnant women who have been diagnosed with syphilis and offer to make house calls to administer antibiotics. DeAnn Gruber, director of the Bureau of Infectious Diseases for the Louisiana Department of Health, said the efforts send the message that “this is a very urgent health-care condition that needs to be taken care of."
In 2017, Nevada saw 21 cases of congenital syphilis, at a rate of 57.9 per 100,000 live births.
That same year in California, more than 280 babies were born with congenital syphilis, including 30 who were stillborn, marking a rise for the fifth consecutive year, according to state and federal data. Texas reported 176 cases, and state health authorities expect the 2018 numbers to be even higher. There were 93 cases in Florida.
Arizona, which is ranked sixth in the country per capita, has seen a significant increase in the number of congenital syphilis cases. In 2017, the state reported 31 cases — nearly double than the year before. That number nearly doubled again last year and, so far in 2019, there have been 55 cases; one of the babies has died. The Arizona Department of Health Services posted an alert warning that medical providers “are seeing the largest increase of syphilis cases in women and newborns.”
Bowen, with the CDC, said that “the situation we have now is an unacceptable one.”
“Given how preventable these cases are with appropriate testing and treatment and the really effective antibiotics we have today, we shouldn’t be here,” she said. The United States was able to get syphilis under control after an epidemic decades ago, she noted, which “gives me hope that we can do this again.”