The unknown cause explained a tragic death that had occurred decades earlier.

Stuck in traffic, she discovered images on her phone that seemed to match her strange symptoms.

One surgeon’s open-mindedness led to a successful fix others had dismissed.

A brain scan prompted a wholesale reevaluation of this woman’s medical history dating back years.

Patients and doctors offer ways to avoid wrong turns in unsolved cases.

A New York handbag designer has struggled to cope with her confusing condition.

Her unusual diagnosis was followed by a long and rocky quest for effective treatment.

Doctors were stumped. Then a specialist 8,000 miles away ordered a revealing scan.

The surprising reason for her retching led a Los Angeles publicist to revamp her lifestyle.

Her fall off the bleachers during high school graduation triggered a search for answers.

A specialist’s blunt questions exposed the prolonged failure to diagnose and treat an elementary school principal for a disease that could have killed him.

Multiple rounds of antibiotics and other measures didn’t eradicate the unexpected source.

A bevy of specialists tried to help but seemed stymied by her symptoms — and their narrow focus.

At first, a Virginia woman was more exasperated than alarmed over her head-turning problem. The unusual cause was something none of her doctors had suspected.

After tripping over a dog and falling, an X-ray raised the prospect of cancer. So why had her intractable hip pain gotten better?

A client’s eagle-eyed examination spotted a critical clue that had been overlooked for years.

The 61-year-old sometimes feels angry about years of ineffective treatments. But he’s grateful that evolving medical knowledge spurred “a diagnosis that seems to make sense.”

Why multiple drugs and repeated treatments failed to stem a Virginia teacher’s alarming deterioration.

A toddler’s puzzling regressions foreshadowed a devastating diagnosis.

NIH physicians found his veins grossly enlarged and too stretchy — but they don’t know why or how to treat it. And they’ve never seen a similar case: He’s “a zebra among zebras.”

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