Italian designer Laura Biagiotti, left, and her daughter Lavinia Biagiotti Cigna walk along the catwalk in Milan in 2015. (Daniel Dal Zennaro/EPA)

Laura Biagiotti, an Italian fashion designer who conquered global markets with her soft, loose women’s clothes and luxurious knits that won her the nickname “Queen of Cashmere,” died May 26 at a hospital in Rome. She was 73.

She suffered a heart attack at her estate outside of Rome two days earlier, her family said.

Ms. Biagiotti began designing women’s clothes in the 1960s and by the 1980s was making her mark. In 1988, she became the first Italian designer to put on a fashion show in China, presenting dresses and blouses in silk and cashmere, and in 1995 was the first to have a show inside the Kremlin walls in Moscow.

She expanded into men’s clothing as well, and created a plus-size women’s line, Laura Piu, and a line for children.

Her company produced sunglasses and other accessories and perfumes, including the popular “Roma” fragrance, named after Ms. Biagiotti’s home city.

A model wears an outfit from the Laura Biagiotti Autumn/Winter 2006-2007 collection, unveiled in Milan. (Alberto Pellaschiar/AP)

Born in the Eternal City on Aug. 4, 1943, she studied to become an archaeologist but abandoned those plans to help her mother run a dressmaking business.

In those early years, she traveled frequently to the United States to learn business and technology. After collaborating with such famous fashion houses as those of Emilio Federico Schuberth and Roberto Capucci, she presented her own collection in Florence in 1972.

“Being a fashion designer is like taking vows. It becomes your religion for life,” she told the Associated Press in 1987.

As a gesture of Italian pride, she wore for years a cashmere shawl woven in the red, white and green colors of the nation’s flag.

Ms. Biagiotti was a pioneer in the now-established practice of fashion houses’ sponsoring restoration of monuments.

Her perfume brand contributed to the restoration in 1998 of the ramp-like staircase, designed by Michelangelo, that leads to the top of the Capitoline Hill. Years later, Ms. Biagiotti contributed to the restoration of the delightful 17th-century, twin fountains that top ancient Egyptian granite baths in front of Palazzo Farnese, considered the finest Renaissance palace in Rome and home to the French Embassy.

Ms. Biagiotti lived in a medieval castle on a hilltop outside of Rome that she had restored, and which was the headquarters for her business.

A model wears a creation as part of the Laura Biagiotti women’s Spring/Summer 2010 fashion collection, as presented in Milan. (Antonio Calanni/AP)

Her husband, Gianni Cigna, who had also been her business partner, died of leukemia in 1996. Survivors include her daughter Lavinia Biagiotti Cigna, who works as the fashion house’s creative director.