Delta offers one-stop flights from Washington Dulles to Venice, with late- October fares currently starting at $1,050 round-trip.
Fondamenta Santa Caterina 3
Isola di Mazzorbo
Intimate villa on a small vineyard, with a gourmet restaurant. Rooms from $190, breakfast included (open March-November).
Isola della Certosa
Relaxed hotel with a cozy bar and lounge. Rooms from $90.
World-class restaurant on a serene vineyard, helmed by a top Italian chef. Entrees from $25.
Il Lato Azzurro
Via Forti 13
Restaurant in a charming guesthouse. Entrees from $10 (book ahead).
I Sapori di Sant’Erasmo
Azienda Agricola Fratelli Finotello
Via Boaria Vecia 6
Farm where you can buy fresh produce and taste wine.
Museo del Merletto
Piazza Galuppi 187
Lace-making museum in the original palace that housed the celebrated school, active from 1872 to 1970. Open 10 a.m. to 6 p.m. until Oct. 31, 10 a.m. to 5 p.m. Nov. 1 to March 31. $6.50.
Isola del Lazzaretto Nuovo
Explore the former plague quarantine island as well as the natural sandbar environs.
Various lagoon tours from Isola della Certosa for groups of two to 12. Half-day $115, full-day $155 per person for two to five people.
Terra & Acqua
Itineraries in a traditional bragozzo include a tour of the Northern Lagoon — Torcello, San Francesco del Deserto, Sant’Erasmo and Lazzaretto Nuovo — departing from Venice’s Squero di San Trovaso. $490 to $540 for a full weekday for up to 12 people; $540 to $590 on Saturday or Sunday.