The Washington region reported a surge of new coronavirus infections Friday, notching the most cases in a single day since the start of the pandemic.

Virginia, Maryland and D.C. added 3,219 new infections, surpassing a daily record that has stood since May 1, when 3,120 cases were reported. Leaders across the region say they are making preparations for a continued increase this winter amid a record-setting national spike in cases.

The greater Washington region has seen caseloads march steadily upward since the start of October, when the seven-day rolling average of new infections stood at 1,313. By Friday, that number had nearly doubled, to 2,424.

The 1,541 new cases reported Friday in Maryland was its most in a single day since May 19 and the third-highest since the start of the pandemic. It lifted the state’s seven-day average number of new cases to 1,027, the most since May 25.

In the past week, Maryland has seen a 17 percent increase in hospitalizations, while its coronavirus test positivity rate of 4.37 percent is the highest since June. Gov. Larry Hogan (R) sounded the alarm about the increase Thursday while urging residents to remain vigilant and follow protocols to slow the virus’s spread.

“It’s just that simple,” Hogan said. “It’s not that hard. Just wear the damn mask.”

In Baltimore, officials on Friday announced new restrictions, set to begin at 5 p.m. Thursday, as the number of hospitalizations and coronavirus cases rise to their highest levels in months.

Mayor Bernard C. “Jack” Young (D) reduced the capacity allowed in restaurants, houses of worship, retail and personal service establishments, gyms, casinos and indoor and outdoor recreational facilities from 50 percent to 25 percent. Indoor service in restaurants must stop at 10 p.m.

“We’re still in a pandemic,” he said. “I know there is covid fatigue but now more than ever I need residents of Baltimore to remain on guard.”

City Health Officer Letitia Dzirasa said Baltimore’s coronavirus metrics are heading in the wrong direction. In the past month, she said, the city is seeing an average of 103 new cases a day and a 73 percent rise in intensive care bed use.

“This data is alarming and requires action,” Dzirasa said.

She said it is critical for residents to do their part to keep the virus at bay, including canceling large in-person holiday gatherings this year.

“Plan to celebrate with your immediate household only,” she said. “Checking in by phone or video may very well save a life.”

D.C.’s 110 new cases Friday lifted its seven-day average number of new infections to 93, the most since early June — but still about half the peak levels of early May.

In Virginia, state health officials reported 1,568 new cases Friday, lifting its seven-day average to 1,304 — the latest in a string of record highs in recent days. Most of the increase has come from Northern Virginia and the state’s mostly rural Southwest. While cases have increased, virus-related deaths in the region have mostly held steady. Maryland on Friday reported 12 fatalities and D.C. reported two new deaths.

In Virginia, the death toll took an unexplained drop Friday, as six fewer deaths were reported. A state health department official said the department is looking into the reason for the decline.

Even as caseloads have jumped across the Washington region, they remain at about half the level of the national average.

Patricia Sullivan contributed to this report.