Seventeen people, including three members of a Washington area family, were arrested Wednesday in an ongoing investigation into an alleged drug ring that stretches from Texas to the District.

The arrests follow two indictments returned this month in federal court that allege that the defendants conspired to distribute heroin, cocaine and marijuana. Law enforcement officials seized more than a dozen guns, heroin, PCP and cash at 17 locations searched Wednesday in Maryland and the District.

Seven others were arrested in McAllen, Tex., on Nov. 18, according to the office of U.S. Attorney Ronald C. Machen Jr.

D.C. Police Chief Cathy L. Lanier called the arrests “significant” and said in a statement that federal and local law enforcement officials are committed to “disrupting criminal organizations intent on wreaking havoc on our neighborhoods for their own personal gain.”

Among the 12 men and five women arrested Wednesday were three members of one family: an alleged leader in the conspiracy, Juan Floyd, 45, of Temple Hills; his brother, John Floyd, 51, of the District; and his daughter, Juanita N. Culbreth, 27, of Oxon Hill.

The defendants face a minimum of 10 years in prison if convicted, according to Machen’s office.