A total of six people were hospitalized Sunday. (Sarah L. Voisin/THE WASHINGTON POST)

During a routine traffic stop in Prince George’s County on Sunday afternoon, a driver suddenly sped off, ultimately causing a multiple-vehicle collision in Southeast Washington that left six people injured, one critically, police said.

The crash occurred about 4:15 p.m. at Southern and Pennsylvania avenues SE at the boundary between Prince George’s and the District. The car that had been stopped by police was driving on Pennsylvania Avenue toward the District when it collided with other vehicles in the major intersection, Cpl. Mike Rodriguez, a Prince George’s police spokesman, said.

At least three other vehicles were involved, including a Metrobus with a driver and four passengers on board, Dan Stessel, a Metro spokesman, said. One passenger was taken to a hospital with minor injuries.

The bus, which had been traveling south on Southern Avenue along the M6 line, appears to have cracked a curb stone, plowed across a median and come to a rest on a grassy strip in front of the Cedar Hill Cemetery.

A police officer who responded to the crash was involved in a second collision when his vehicle was hit by a car making a U-turn, Rodriguez said. The officer was taken to the hospital with minor injuries.

A total of six people were hospitalized Sunday: One adult with life-threatening injuries and two adults and three children with minor injuries, Lon Walls of D.C. Fire and Emergency Medical Services said. Walls said he did not know which vehicles those people were in.

The center of the intersection was blocked from traffic Sunday evening as crews cleared the wreckage.