The pedestrian, who was identified as Brett Richard Badin, 32, of Rockville, died at the scene, police said. The driver and a passenger in the Accord were not injured.
The crash remains under investigation, police said.
The collision follows another one a day earlier on another stretch of Rockville Pike.
In that incident, a driver in a Nissan Sentra was traveling southbound on Rockville Pike shortly after 8:40 p.m. Wednesday when his vehicle hit a pedestrian who was attempting to cross the roadway in the 12200 block, police said.
The pedestrian, Michael Louis Gamboa, 40, of Gaithersburg, was taken to a hospital, where he died of his injuries, police said. The driver remained on the scene after the crash. He was not injured.
Detectives continue to investigate the crash, and no charges have been filed, police said.
Anyone who witnessed the collision or has additional information is asked to contact the Montgomery County police Collision Reconstruction Unit at 240-773-6620.
The fatal collisions were among a spate of incidents in recent days on Montgomery County roads.
Also on Wednesday, the Montgomery County Fire Department reported that a cyclist was struck at Wootton Parkway and Dundee Road in Rockville shortly after 7 p.m. Earlier, an adult pedestrian was also struck on Towne Road in North Bethesda shortly after 6:20 p.m., the fire department said. And a toddler was hit by a car about 5:45 p.m. Wednesday in the 4300 block of Willow Lane in Chevy Chase, the fire department said. All three collisions resulted in injuries.
Clarence Williams contributed to this report.