One day next week, after they arrive in China, Laurie Thompson hopes to get a few minutes alone with Bei Bei, a giant panda at the National Zoo.

It will be a farewell for both, and the end of an era for the zoo, where Thompson has worked for almost 25 years.

She and Bei Bei have been together since he was born four years ago. She held him when he was a hairless cub. She was the one who called the veterinarians when he got sick one Thanksgiving Day and was with him in the operating room for his surgery.

They know each other well. He comes when she calls and squawks if he wants something. She says he’s a good boy.

Next week, she will accompany Bei Bei on the plane that will carry him to his new home in China and close, for now, the illustrious reign of the giant panda cub in Washington.

“I think there’s going to be some tears,” Thompson, the assistant curator of giant pandas and the zoo’s longest-serving giant panda keeper, said Monday. “To leave him in a new place, although I know he’ll be getting great care, it’s just sad.”

Bei Bei is the last of the zoo’s three giant panda cubs to depart, and he could be the last cub in Washington for a while, closing a joyous chapter in local history that began 14 years ago.

China owns and leases all giant pandas in U.S. zoos. The animals, and especially their cubs, have been part of the relationship between the two countries through good times and bad, from the Cold War to the current trade tensions.

But the zoo has not had a cub since Bei Bei was born in 2015.

Its adult giant pandas — the female, Mei Xiang, and the male, Tian Tian — did not produce one this year.

Zoo officials announced in September that Mei, after being artificially inseminated in March, had a false pregnancy, in which she exhibits all the signs of pregnancy but is not really pregnant.

She also had a false pregnancy last year, and the year before, and as many as six other times previously.

“Mei Xiang is of an advanced maternal age,” zoo spokeswoman Annalisa Meyer said in an email Monday. “It’s unlikely she will get pregnant again.”

It’s not clear how, or if, the zoo would get giant panda cubs again. Nor is it clear whether the Chinese will want the two adults back when their extended lease expires next year on Dec. 7. Both were born in China.

“It’s hard to say what’s going to happen,” Thompson said. “Right now we don’t know if there will be another extension of our adults or if we will have to send them to China, and if we will get new pandas.”

The National Zoo has had giant pandas almost continuously for 47 years.

Thompson cannot envision the zoo without them. “I really can’t,” she said. “I don’t want to.”

Under the agreement with the Chinese, all giant panda cubs born in U.S. zoos must be sent to a breeding program in China once they turn 4. Bei Bei turned 4 on Aug. 22. He leaves on a 16-hour nonstop flight on Nov. 19.

Two of the zoo’s cubs have already been shipped to China — Tai Shan in 2010 and Bao Bao in 2017.

On Monday, after Thompson, 48, had knelt before an enclosure, feeding Bei Bei chunks of apple, she reflected on her years with him and her almost quarter-century caring for the zoo’s famous black-and-white bears. She will continue caring for the remaining giant pandas after Bei Bei leaves.

“It’s the best job you could ever have,” she said.

A native of the Annapolis area and would-be marine biologist, she started at the zoo in 1994. She witnessed the final years of Hsing-Hsing, who with his mate, Ling-Ling, had been gifts from China during the administration of President Richard Nixon in 1972.

Ling-Ling had died in 1992. Hsing-Hsing died in 1999. “He was actually a very sweet bear,” she said. “Very laid-back, but also playful . . . kind of silly, even in his old age. But he was just a really nice guy.”

Mei Xiang and Tian Tian arrived via a lease in 2000.

The 2005 birth of Tai Shan, a male, set off panda cub delirium in Washington.

Bao Bao, a female, was born in 2013.

But it was Bei Bei, born with a short-lived twin in 2015, who got closest to Thompson, she said.

His arrival was dramatic. Mei Xiang had already delivered one cub that day, and it was Thompson, watching on a panda video camera, who discovered that she had unexpectedly delivered another. “We were just sitting in the office and watching Mei Xiang on the camera, and it was like, ‘Something’s happening,’ ” she said. “You could hear vocalization, and I looked up and she popped out another cub.”

“We were like, ‘Ahhh!’ ” she said.

Giant panda mothers have trouble rearing more than one cub, so the keepers would retrieve one cub so Mei could focus on the other, and then switch them back. They used a device like a lacrosse stick to help make the exchanges, Thompson said.

After one switch, Thompson, wearing a blue surgical gown, held Bei Bei while a veterinarian examined him. She had never held a cub so young. He was hairless and looked like a naked mole rat, she said.

“He was squawking and making a lot of noise,” she said. “I was trying to figure out how to hold him and keep him calm, and the whole time going, ‘I’m holding a panda cub!’ ”

(The other cub, which was smaller, died four days later after suffering respiratory problems.)

The following year, on Thanksgiving Day, Thompson was on duty and saw Bei Bei vomiting. “Pandas really don’t vomit often,” she said. He had also been listless.

She summoned zoo veterinarians, and Bei Bei was taken to the zoo’s animal hospital for emergency surgery the next morning.

She went with him and was in the operating room as the surgeons worked.

“I stayed back,” she said. “I didn't really want to [see] the gory parts. . . . You wouldn’t want to watch your child’s surgery.”

The doctors removed a wad of partially digested bamboo that had gotten stuck in Bei Bei’s intestine.

Thompson and colleagues were relieved.

“We were afraid somebody threw something in the yard, or he found something and chewed on it and swallowed it,” she said.

He recovered fully.

On Monday, Bei Bei, who now weighs 240 pounds, sat inside an enclosure, gripping the metal mesh with his huge claws as Thompson fed him the chunks of apple. He squawked for some more. She told him how smart he was.

Once they get to China, she said, she wants to tell the new Chinese keepers about Bei Bei’s quirks — how he likes to climb trees, doesn’t like his feet to be touched and detests frozen bananas.

“I don’t know if they’ll give him bananas,” she said.

Read more: