A tour bus that had left from Washington crashed on a highway in western New York state Sunday, leaving at least two people dead and as many as three severely injured, authorities said.

The bus was carrying 37 people en route to Niagara Falls.

No names were available for the victims. A state police trooper said it appeared that most or all of the passengers might have been from India. Indian diplomatic officials reached Sunday night said they had no information to confirm that.

A trooper said the bus was traveling north on Interstate 390 in the Avoca area when the single-vehicle crash occurred about 4 p.m. The site is about 60 miles south of Rochester, N.Y.

The trooper, speaking from the police barracks in Steuben County after returning from the crash scene, said initial reports indicated that the bus might have gone out of control after a tire blew out.

After leaving the road, he said, the bus went down an incline into a wooded area and tipped over.

One of the rescue workers sent to the scene said he saw tire debris on the roadway, near where skid marks began.

He said some passengers were brought out the bus door, while others required extrication. It appeared that everyone on board suffered some injury, he said.

Published reports said the bus company was based in New York.

Karin Christensen of Strong Memorial Hospital in Rochester, the area’s main trauma center, said that three of the four were in guarded condition. Two more patients were to be transferred there overnight, she said.