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The coronavirus has infected at least 450,000 heath-care workers worldwide, according to a report issued Wednesday by an international nursing federation, a new insight into the toll of the pandemic and against those fighting it. Overall, more than 6.4 million cases of covid-19 have been confirmed, including at least 381,000 deaths.

Meanwhile, a study published Wednesday in the New England Journal of Medicine found that hydroxychloroquine did not prevent healthy people exposed to covid-19 from getting the disease caused by the coronavirus. The study is the first randomized clinical trial that tested the antimalarial drug, which President Trump touted, as a preventive measure.

In the United States, more than 1.8 million coronavirus cases have been reported, with recent increases seen in states such as Arizona, Florida and Mississippi. The return to economic and social activities, as well as widespread protests of police brutality, continue to raise concern among some health officials of further spread.

Here are some significant developments:

  • Wall Street wrapped up a remarkable 50-day run, posting a 40 percent advance that signals optimism against the downward pull of disease, civil unrest and economic deterioration.
  • George Floyd, whose death in police custody sparked widespread protests around the world, tested positive for the coronavirus in April, according to the full autopsy report released Wednesday by the Hennepin County (Minn.) Medical Examiner. The autopsy found Floyd likely had “asymptomatic but persistent … positivity” from that past infection, the report states.
  • Brazil reported a record 1,262 new coronavirus-related deaths to raise its total to at least 31,199, third-most in the world. It now has at least 550,000 confirmed cases, behind only the United States. “We lament all deaths, but it’s everyone’s destiny,” President Jair Bolsonaro told supporters.
  • U.S. companies shed 2.76 million jobs from April to May, according to management services company ADP’s private payroll report, a figure that came in well below analyst estimates but still exposed the devastation of the coronavirus recession. Large businesses, which employ 500 people or more, bore the brunt of those losses at 1.6 million.
  • The architect of Sweden’s unique anti-lockdown approach to fighting the coronavirus said that in light of the large numbers of dead, he should have advised more restrictions on society to protect lives. Sweden has reported upward of 38,000 coronavirus cases and 4,468 deaths, giving it a far higher per capita death rate than its Nordic neighbors, which all introduced mandatory lockdowns.

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