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In a rare and extraordinary rebuke, seven former commissioners of the Food and Drug Administration wrote an op-ed accusing the Trump administration of interfering politically with the agency, with potentially catastrophic effects on public trust in a coronavirus vaccine.

The column, which was published online Tuesday afternoon in The Washington Post, detailed a recent pattern of interference, including President Trump’s threat to reject a proposed FDA guidance detailing the criteria the agency will use to judge a coronavirus vaccine, and decisions by Health and Human Services Secretary Alex Azar to revoke the FDA’s authority to regulate lab-developed tests and to sign its own rules.

Here are some significant developments: