In one week, new daily coronavirus cases in the United States went from 104,000 to more than 145,000 on Wednesday, the latest all-time high. Almost every metric is trending in the wrong direction as states add restrictions and health officials warn of a dangerous fall ahead.

The rise in infections comes with new highs in the number of deaths reported in a single day at 1,549, the highest since May 14. Tennessee, Alabama and Minnesota all reached new highs in the number of deaths reported in a single day.

Here are some significant developments: