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Pediatricians are preparing to administer the nation’s first coronavirus children’s vaccine to 5-to-11-year-olds as early as Wednesday after the Centers for Disease Control and Prevention signed off Tuesday night on giving the Pfizer-BioNTech shots to 28 million children.

The go-ahead from CDC Director Rochelle Walensky is a watershed moment in the fight against the pandemic, which has killed 745,000 people in the United States and infected nearly 2 million kids. Millions of families have waited for a children’s vaccine since the first adult shot was authorized last December, hoping their kids could finally resume in-person schooling and extracurricular activities without interruption — and that their own work schedules could become more predictable.

Walensky’s recommendation came hours after the agency’s vaccine advisory panel unanimously recommended the Pfizer BioNTech’s pediatric vaccine for younger children.

Here’s what to know