Researchers have found that many astronauts who do a six-month mission in space come back with a condition that causes blurred vision. (Whitney Shefte/The Washington Post)

In 2005, astronaut John Phillips took a break from his work on the International Space Station and looked out the window at Earth. He was about halfway through a mission that had begun in April and would end in October.

When he gazed down at the planet, Earth was blurry. He couldn’t focus on it clearly. That was strange — his vision had always been 20/20. He wondered: Was his eyesight getting worse?

“I’m not sure if I reported that to the ground,” he said. “I think I didn’t. I thought it would be something that would just go away, and fix itself when I got to Earth.”

It didn’t go away.

During Phillips’s post-flight physical, NASA found that his vision had gone from 20/20 to 20/100 in six months.

John Phillips began experiencing sight issues during his time on the International Space Station in 2005, but was reluctant to say anything while in space. (NASA)

Rigorous testing followed. Phillips got MRIs, retinal scans, neurological tests and a spinal tap. The tests showed that not only had his vision changed, but his eyes had changed as well.

The backs of his eyes had gotten flatter, pushing his retinas forward. He had choroidal folds, which are like stretch marks. His optic nerves were inflamed.

Phillips’s case became the first widely recognized one of a mysterious syndrome that affects 80 percent of astronauts on long- ­duration missions in space. The syndrome could interfere with plans for future crewed space missions, including any trips to Mars.

Visual impairment intracranial pressure syndrome (VIIP) is named for the leading theory to explain it. On Earth, gravity pulls bodily fluids down toward the feet. That doesn’t happen in space, and it is thought that extra fluid in the skull increases pressure on the brain and the back of the eye.VIIP has now been recognized as a widespread problem, and there has been a struggle to understand its cause — and even to study it.

The theory that fluid builds up in the skull during spaceflight hasn’t been tested. The only proven methods of measuring intracranial pressure are invasive: the spinal tap or drilling a hole into the skull.

Before-and-after images of an astronaut’s eyes via spectral domain optical coherence tomography show choroidal folds (marked by arrows), which are similar to stretch marks. (Courtesy North American Neuro-Ophthalmology Society)

“There’s the risk for infection and just doing the procedure, quite frankly, in space is difficult,” said J.D. Polk, a senior flight surgeon at NASA. “Having to anchor somebody and do a spinal tap in space is not something we would relish.”

Here on Earth, the most similar condition is idiopathic intracranial hypertension (IIH). Patients with this condition have increased pressure in their heads and experience visual changes. Another condition, papilledema, involves optic nerve swelling.

But they are not perfect models for the astronauts’ disorder. IIH comes with a deluge of other symptoms, including nausea, dizziness and severe headaches, that astronauts with VIIP do not experience. And the medication for papilledema, optic-nerve swelling, does not work on VIIP.

Karina Marshall-Goebel at the Institute of Aerospace Medicine in Germany is trying to study VIIP using a head-down tilt test, in which participants’ bodies are tilted slightly to simulate the fluid shift in space. But the test is still affected by gravity, and researchers cannot keep people tilted for as long as astronauts live in space. “It’s a unique environment; you can’t replicate it without going into space,” she said.

Other researchers are searching for less-invasive ways to assess brain health on Earth and, potentially, in space. Devices being developed use sound waves and radio waves to attempt to measure the brain at its different access points: the skull, ears and eyes. One estimates brain pressure by pushing on an anesthetized eye until a vein flattens, sort of like stepping on a gardening hose.

“So far, none of the noninvasive technologies are accurate enough to replace the invasive measurement, but I think within the next few years there is a good chance there will be,” said Eric Bershad, an intensive-care neurologist at the Baylor College of Medicine, who is working on a way to measure brain pressure using an ultrasound test on an eye artery.

Ross Ethier, a biomedical engineer at Georgia Tech, is looking at a potential mechanical solution: a device that could draw fluid back down to the legs in space. It would likely be clunky and uncomfortable, so he would need to know how long a person would have to wear it — two hours a day? Three?

“Right now, there’s a million things you could measure, and you kind of don’t even know where to start,” Ethier said.

Michael Barratt, an astronaut and the former head of NASA’s human research program, was on a six-month mission on the space station in 2009 when he noticed his vision deteriorating. He and a crewmate, Bob Thirsk, were both medically trained.

“We’re thinking to ourselves, ‘Are we not physicians?’ ” Barratt said. “So we did ophthalmoscopic exams on one another.” They both found hints of a swollen optic nerve. After NASA sent up more imaging equipment, they discovered the classic VIIP syndrome — the flattening of the eye shape and optic-disc edema — in each other.

Barratt thinks that solving the puzzle of VIIP is going to require testing intracranial pressure in space, even if that means an invasive procedure. One option is an intracranial probe that would be surgically implanted months before flight and allow pressure to be measured at different points during spaceflight.

“This is one of those times I think aggressive science is extremely warranted,” Barratt said.

A study of intracranial pressure during a parabolic flight, which achieves zero gravity for about 25 seconds, took advantage of scalp implants that four men had for other medical reasons. The results showed an initial spike in pressure, but during zero gravity, intracranial pressure went down. It was a confusing result, the opposite of what was expected.

Barratt draws parallels to a similar conundrum from the 1990s, when it was unclear how the pressure in the heart was affected by space flight. NASA performed an invasive test, inserting catheters into the hearts of astronauts.

“We took that risk then, purely for science, and now we’re faced with a similar risk decision,” Barratt said. “But in this case it’s not just a science project, it’s a medical issue, which is arguably our number two risk in human spaceflight right now.”

The top risk remains radiation exposure. According to a radiation detector that flew aboard the Mars Curiosity Rover, a human would be exposed to a minimum of 0.66 sieverts to get to Mars and back — the equivalent of getting a whole body CT scan every five to six days, which would heighten the risk for cancer and other diseases.

Before a human trip to Mars — a journey of six-to-nine months that NASA wants to achieve by the 2030s — researchers agree that VIIP must be understood better.

VIIP could be the first sign of greater dangers to the human body from microgravity. “We’re seeing the visual and neural, ophthalmic manifestations of it,” Barratt said. “I’m fairly certain this is a bit more global than that.”

Richard Williams, the chief health and medical officer at NASA, agrees that what we do not know about VIIP still poses the biggest threat. Ironically, one of the only ways to get more knowledge is spend more time in microgravity. “The longer we stay in space, the more we’re going to learn,” Williams said.

It took about six months back on Earth, but Phillips’s vision did improve a little. It went from 20/100 to 20/50, and it has remained there for the past 11 years. He cannot pass a DMV eye exam without glasses.

But he and other astronauts say that they would not trade their time in space to get back the lost acuity. Astronaut Michael Lopez-Alegria holds the U.S. record for the most time spent doing spacewalks. He called being in microgravity “magical.” He wears contacts with a +2.5 correction.

Phillips now considers himself just another 65-year-old with glasses. But before his trip in 2005, he was always used to being the guy with the best vision, the first one in the car to read a street sign. “So that era was over,” he said.