Marge: “This is the worst thing you’ve ever done.”
Homer: “You say that so often that it’s lost all meaning.”

IF LOVE is a drug, then Homer Simpson is smitten with his new dealer.

After the nearly three decades, and three never-aging tykes, they have had together, TV’s longest-running couple is calling it Splitsville. (“Mmmm…a tasty split. “)

Yes, Marge will be as blue as her towering beehive, because Homer seeks a cure for his narcolepsy, and soon “falls in love” with the woman who can treat what ails him: a pharmacist voiced by “Girls” actress-writer Lena Dunham.

“In the [season] premiere, it’s discovered after all the years Homer has narcolepsy and it’s an incredible strain on the marriage,” show-runner Al Jean told Variety. So, “Homer and Marge legally separate.”

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Homer and Marge have physically split before — such as when Alaska beckons in “The Simpsons Movie” — but have never legally separated. That doesn’t mean, however, they’ve never divorced. Marge and “Homey,” in fact, are coming up on the 20th anniversary of their divorce. Yes, in the 1996 episode titled “A Milhouse Divided,” Homer secretly divorces Marge, but ultimately as a romantic gesture — so that their remarriage can be better than their first nuptials, when they had a truck-stop reception. And then, just six years ago, in “Wedding for Disaster,” we learned that the Rev. Lovejoy lacked a valid license at the remarriage, so the Simpsons, technically — or as technical as one can get in episodic Springfield — had been divorced for more than a decade.

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(And if pressed to guess, we’d say that this fall’s separation will be a one-episode lark, and that Homer won’t be a candidate for the Divorced Dad’s Visitation Jamboree any decade soon.)

Jean’s spilled beans (“Mmm…beans.”) comes just days after the show revealed that Sideshow Bob will kill Bart in a Halloween special. Jean also teased that in the forthcoming season, Lisa will become pals with a homeless woman who has an amazing singing voice (“SNL’s” Kate McKinnon voices the words; Natalie Maines of the Dixie Chicks belts out the notes) — and a “Boyhood” parody will be built around Bart.

The new season — which presumably will soldier on without departing “man of many voices” Harry Shearer — begins in September.

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