The bridge project requires a traffic detour near Washington Adventist Hospital in Takoma Park.
As road work season gets underway, they warn about dangers in construction zones.
The lanes will close for a water main project on East West Highway.
Lane closings near the University Boulevard interchange are scheduled to begin Sunday and last about a month.
A nine-mile stretch of the busy commuter route will be expanded from two to four lanes.
Numerous people were injured.
Multiple people were injured in the pileup. A firetruck responding to the scene was hit by a car.
The Monday afternoon game is likely to provide an exception to a week of light traffic.
A driver whose car collided with a Metro bus at the intersection of Powder Mill Road and Pleasant Acres Drive was trapped, but is now on way to trauma center with possible life-threatening injuries. Six passengers on bus were also taken to the hospital.
Watch for extra traffic during the evening commute. Metrorail will stay open late for football fans.