I-95 drivers in Virginia, and Red, Orange Line riders on Metro will encounter work zones.
A heavy schedule of Saturday events features the annual Komen Race for the Cure around the Tidal Basin.
The weather won't interfere with weekend travels, but note some Metrorail and highway work.
Metro work will affect two lines, while holiday travelers should be ready to encounter major delays on Sunday.
The weekend will get off to a rainy start, while events will close many D.C. streets and Metro work will lead to long waits.