Losing the game was bad enough, but losing Santonio Holmes could really hurt New York’s struggling offense. (Bill Kostroun/AP)

The X-rays came back negative, but the New York Jets still do not know the full extent of the foot injury wide receiver Santonio Holmes suffered in Sunday’s blowout loss to San Francisco.

Early in the fourth quarter Holmes caught a pass from Mark Sanchez but appeared to lose his footing when he turned up-field. As he fell to the turf, he flipped the ball into the air and 49ers defensive back Carlos Rogers scooped it up and ran 51 yards for a touchdown (video on NFL.com here).

Seth Walder of the New York Daily News reports the team is sending Homes’ MRI to several places while Rex Ryan says they are “trying to figure out exactly what it is.”

“I’m not sure how many weeks he’ll be out, the real extent of the injury,” Ryan said. “We just know the X-rays were negative. That’s good news. Obviously, it looks doubtful for this week.”

Doctors have ruled out an Achilles tendon injury, ESPN reports, but another ligament problem or Lisfranc injury could keep Holmes out for an extended period, and Ryan told reporters the team is hoping the injury is muscular and not ligament related.

After limited production in Weeks 1 and 2, Holmes exploded for 147 yards on nine receptions in the team’s Week 3 overtime win at Miami. Jeremy Kerley (10 receptions, 197 yards) is the only other Jets receiver with at least 100 receiving yards this season.

Mark Sanchez is also crossing his fingers that his top target returns soon. Against the 49ers, he completed only 13 of 29 passes for an abysmal 103 yards and one interception. The Jets now rank 26th in the league in passing offense with 197.5 yards per game.

Ryan’s frustration boiled over in Sunday’s post-game press conference.

“I was going to say we got our butt kicked, but really … there’s no two ways, in or outs about it,” Ryan said.

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