He did it with a wink, a smile and style. Stuart Scott, the anchor who energized ESPN’s sportscasts with a fresh vibe filled with pop-culture references and catchphrases so out of the norm that viewers and sometimes his bosses didn’t know what to make of him, died Sunday of the cancer he had fought three times over the past seven years.

Scott, 49, was one of the most recognizable and popular faces of ESPN, eventually joining the network’s “SportsCenter” and NFL and NBA shows. The highest-profile black sportscaster at the network, he joined ESPN in 1993 and his exuberant expressions, like “booyah,” cool as the other side of the pillow” and “just call him butter ‘cause he’s on a roll,” became his trademarks. It was a different tone, something LeBron James called an unmistakable “swag.” Scott “didn’t push the envelope,” former ESPN anchor Dan Patrick said in a video tribute produced by the network, “he bulldozed it.”

“While he is now considered a trailblazer, he was once considered a leper,” his former colleague, Bonnie Bernstein, wrote on Facebook. “ESPN executives didn’t know what to make of him in the early ’90s. The hip-hop slang. The catchphrases the bosses didn’t understand. BOOYAH! What the hell does that mean?? Stu also had a polarizing effect on the air. There were plenty of viewers out there who felt Stu’s shtick was like proverbial nails on a chalkboard.

“And Stu knew it. We would talk about it. But you know what? He never wavered. Not one bit. He actually reveled in it. I always admired that about him and hoped the bosses would come to understand what I saw when Stu and I were on the road together covering the NBA Playoffs. The guy was a superstar. The black players and the fans would flock to him. His star was as bright as Jordan’s. Or Shaq’s. Finally, there was someone on the air who spoke their language. It was incredibly refreshing.”

Scott’s death resonated with top sports stars, so many of whom had seen him work firsthand through bouts with the disease. Kobe Bryant, Kevin Durant, Tiger Woods and Michael Jordan, among so many, tweeted their sympathy. “I’m so sad to hear the news that Stuart has passed away,” Jordan said in a statement. Like Scott, he had attended the University of North Carolina. “He was truly a trailblazer in his field and, by refusing to change his style, made himself into a star. I always enjoyed sitting down to talk to him. But to me he wasn’t just a broadcaster, he was an old friend who I’d known since college. He fought so hard against cancer and I hoped he’d win the battle. I sent my sincerest condolences to his daughters, Taelor and Sydni, and his family and friends. Booyah, my brother.”

President Obama added that he would miss Scott, saying in a statement released by the White House: “Twenty years ago, Stu helped usher in a new way to talk about our favorite teams and the day’s best plays. For much of those twenty years, public service and campaigns have kept me from my family — but wherever I went, I could flip on the TV and Stu and his colleagues on ‘SportsCenter’ were there. Over the years, he entertained us, and in the end, he inspired us — with courage and love. Michelle and I offer our thoughts and prayers to his family, friends, and colleagues.”

ESPN President John Skipper said in a statement: “ESPN and everyone in the sports world have lost a true friend and a uniquely inspirational figure in Stuart Scott. Who engages in mixed martial arts training in the midst of chemotherapy treatments? Who leaves a hospital procedure to return to the set? His energetic and unwavering devotion to his family and to his work while fighting the battle of his life left us in awe, and he leaves a void that can never be replaced.”

Scott’s cancer was first diagnosed when his appendix was removed in 2007. It recurred four years later and again in 2013. Scott fought the disease by working himself into shape with a mixed martial arts regimen that helped him cope with 58 infusions of chemotherapy and three extensive abdominal surgeries. He did not, he told the New York Times last March, know his prognosis.

“I never ask what stage I’m in,” he said then. “I haven’t wanted to know. It won’t change anything to me. All I know is that it would cause more worry and a higher degree of freakout. Stage 1, 2 or 8, it doesn’t matter. I’m trying to fight it the best I can.”

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The fight limited his appearances on the network and they became increasingly infrequent. “There are some days when I say, I don’t know how he’s doing it,” Mark Gross, a senior vice president for production, told the Times in March. Yet he was ubiquitous even in his absence on the broadcasts, as recently as last month, when his “NFL Countdown” colleagues paid an emotional tribute to him before a Monday night game. Suzy Kolber, Steve Young, Trent Dilfer and Ray Lewis were joined by other crew members as Kolber broke down, saying: “I have the privilege of sitting in [Scott’s] seat each week as he fights the fight with cancer. It’s been seven years and Stuart is the recipient of the Jimmy V Award for perseverance and he said in his amazing speech . . . that sometimes when you don’t have the strength you need your friends to step up a little bit and help you. So, Stuart, we want you to know we’re sending you some extra strength and to keep fighting that fight.”

Only in the past year or so had Scott gone public with his private battle, opening up about it in the stirring speech that Kolber mentioned when he was given the Jimmy V Perseverance Award at the ESPYs in July. (That award is, of course, named for Jim Valvano, the North Carolina State basketball coach who died of cancer in 1993.) He was, as the network’s Sage Steele noted in the ESPN video tribute, terribly ill at the time and his appearance was in doubt until the last minute. But this was Stuart Scott. “He owned it,” Steele said of the moment. “It was Stuart and it was perfect.”

“When you die, it does not mean that you lose to cancer,” Scott told the audience. “You beat cancer by how you live, why you live, and in the manner in which you live.”

In his third battle with the disease, Scott admitted at the ESPYs that he thinks of cancer “20 hours a day,” and offered his thanks to his family, his ESPN family and others. He fought, as he so clearly put it, for his two teenaged daughters, one of whom he brought onto the stage that night.

“This whole fight, this journey thing, is not a solo venture,” he said. “This is something that requires support.”

In November, it was erroneously reported that he had entered hospice care and Scott shot back with a tweet that marked his seven-year-long attitude.

“Hospice? No. fighting? YES!”

Scott’s daughters survive him, as does his girlfriend, Kristin Spodobalski; his parents; his sisters, Susan Scott and Synthia Kearney; and his brother, Stephen. Upon learning that Scott’s battle had ended Sunday morning, his former “SportsCenter” partner, Rich Eisen, delivered a raw and powerful tribute on the NFL Network, where he works now. Scott, he said as he choked back his emotions, lived joyfully and without fear.

“I loved this man. I still love this man,” Eisen said. “The fact that he has passed away is absolutely mind-boggling and a travesty. He battled cancer as bravely as anybody else. I know there are many people out there battling cancer right now and Stuart would want you to know to keep fighting, to keep fighting and that he didn’t lose this battle to cancer. He fought it as bravely as he possibly could.

“And as you go to bed tonight, flip your pillow over to the cool side and before you go to sleep, as Stuart would say, you hit your knees tonight and pray to the Big Man for his beautiful daughters whom he loved, Taelor and Sydni. Pray for Stuart and his family, his parents, his siblings, his girlfriend, his ex-wife, everybody who he loved. That includes you the sports fans, even those who hated on him. He thrived on it. That’s because he is who he is and he was who he was. I can’t believe that’s past tense.

“Stuart Scott, dead at the age of 49. I love you Stuart. Wherever you are, godspeed. Rest in peace.”