No. 17 Iowa may have suffered a major loss Saturday after running back Jordan Canzeri went down with what looked to be a fairly serious foot or ankle injury in the first quarter against Northwestern. He was carted to the locker room, which never is a good sign.

Canzeri entered Saturday ranked 20th in the nation and third in the Big Ten at 116.17 rushing yards per game.

Iowa has thrived this season despite a number of big injuries: