Buffalo Bills offensive lineman Seantrel Henderson has overcome two surgeries during the offseason to address the complications he suffers from Crohn’s disease, but will miss one-quarter of the NFL season for violating the league’s substance-abuse policy.

The NFL announced Friday that Henderson will serve his four-game suspension in Weeks 1-4 of the season.

Henderson, who dropped his appeal, was hoping to compete for a starting spot after having surgery to remove 2 1/2 feet of his his colon in January and having surgery to reattach his intestines in April. He tested positive, according to some reports, for marijuana, but ESPN reports that was only part of the issue.

His agent, Brian Fettner, explained to ESPN’s Adam Schefter why Henderson is moving forward with the suspension.

“Merciful or not, there is no medical exception that the NFL will accept. It doesn’t matter that Seantrel is battling Crohn’s disease, and has had his intestines outside his body. It doesn’t matter how you take it, if you digest the cannabis, that’s it. And they don’t care. So you can appeal and lose, and push it back, or you can get it over with. Per the negotiated letter of law, it seems like a futile appeal. We don’t want to waste anyone’s time. We want Seantrel back as soon as possible.”

Over the course of his illness, Henderson lost nearly 50 pounds and had to wear an ileostomy bag until April.

“I was weak,” Henderson, who missed the final five games of the 2015 season with Crohn’s problems, told the Palm Beach Post. “At first I couldn’t stand up on my own. I felt so weak. It was terrible. I didn’t like it at all. I kept walking and walking around the hospital.”

ESPN reported that Henderson, 24, tested positive for marijuana at the NFL combine in 2014 and was suspended for failed drug tests during his playing days at the University of Miami.

“We’ll be prepared for whatever happens, obviously,” Coach Rex Ryan said. “For us, any time, with any situation, our board is set up to where you got the top free agents available — whatever the situation is, through injury or whatever — our pro personnel department is on top of it.”