Sen. Joe Manchin (D-W.Va.) (Reuters)

Sen. Joe Manchin (D-W.Va.), who has been perhaps the leading Democratic skeptic of the health-care law, on Sunday gave Secretary of Health and Human Services Kathleen Sebelius a vote of confidence.

Amid GOP calls for Sebelius to step down or be fired, Manchin said on ABC's "This Week" said Sebelius will succeed.

"I think she should stay, and I think she will get the job done," Manchin said. "I think she needs to bring people around here, and I think she can do that."

At the same time, Manchin said Sebelius's recent statement that she doesn't work for the people calling for her resignation was "unfortunate."

"I think it was unfortunate the comment -- the way it came out," Manchin said.

Manchin has called for a one-year delay in the individual mandate, which requires Americans to pay a penalty if they are uninsured.