The comments came the same day that Ryan, who heads the House's budget committee, unveiled a spending proposal that would slash more than $5 trillion in federal spending over the next decade — mostly by repealing President Obama's signature health law.
"We'll have to see how much of the Koch brothers' agenda is reflected in this new budget," Reid said. "You don't have to be a fortuneteller to know the similarities are extensive."
The remarks are the latest of a number of attacks leveled by Reid and other top Democrats as they attempt to discredit the Kochs, who have pledged millions of dollars in funding for Super PACs that are opposing vulnerable Democrats in this year's midterm elections.
Reid seized on the fact that Americans for Prosperity, a Koch-affiliated PAC, has been running ads in Nevada attacking him.
"These two mogul multimillionaires are so eager to force their will on the American people that they'll do it even in the face of their own hypocrisy," Reid declared. "I am beginning to think April Fools Day arrived early."